Symposium : The Second Nagasaki Symposium   The Second Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and Radiation Life Science Program Venue: Pompe van Meerdervoort Hall Nagasaki University School of Medicine Day 1 (26 July 2006) 10:00-11:10 Opening ceremony Chair: Ichiro Sekine, Nagasaki University, Nagasaki, Japan 10:00-10:40 Opening address   Hiroshi Saito, President, Nagasaki University, Nagasaki, Japan Addresses   Naohito Kimura, Director, Ministry of Education, Culture , Sports, Science and Technology, Japan Yoshiharu Yonekura, President, National Institute of Radiological Sciences, Chiba, Japan Toshiteru Okubo, Chairman, Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan Kenzo Kiikuni, Chairman, Sasakawa Memorial Health Foundation, Tokyo, Japan Shigenobu Nagataki, Executive Director, Japan Radioisotope Association, Tokyo, Japan 10:40-11:10 Overview of COE program   The seven projects and their achievements in five years that provide new Post COE concepts   Masao Tomonaga, Program Leader, Nagasaki University, Nagasaki, Japan   11:10-12:30 Group photo, Lunch, Press conference   12:30-13:30 Keynote lectures Chair: Shigeru Katamine, Nagasaki University, Nagasaki, Japan   Post-COE: World health and radiation environment   Shunichi Yamashita, World Health Organization, Geneva, Switzerland The first target of radiation carcinogenesis is not DNA Non-targeted effect   Masami Watanabe, Kyoto University, Osaka, Japan   13:30-15:50 Reports from the former USSR countries Chair: Yoshisada Shibata and Noboru Takamura, Nagasaki University, Nagasaki, Japan   Thyroid cancer after Chernobyl   Pavel Bespalchuk, Belarusian State Medical University, Minsk, Republic of Belarus Childhood thyroid cancer in Belarus   Yuri E. Demidchik, Belarusian State Medical University, Minsk, Republic of Belarus Radiological health effects 20 years after the Chernobyl accident: Data of the National Radiation and Epidemiological Registry   Marat A. Maksioutov, Medical Radiological Research Center of RAMS, Obninsk, Russian Federation Thyroid gland and radiation (fundamental and applied aspects). 20 years after the Chernobyl accident   Mykola D. Tronko, Institute of Endocrinology and Metabolism, Kiev, Ukraine Chernobyl: ongoing problem of non-cancer diseases   Volodymyr G. Bebeshko, Research Center for Radiation Medicine of AMSU, Kiev, Ukraine Health condition of the population and some outcomes of the international collaborative research programs in the Semipalatinsk Region of Kazakhstan   Murat K. Teleuov, Semipalatinsk State Medical Academy, Semipalatinsk, Republic of Kazakhstan   15:50-16:10 Coffee break   16:10-17:30 Studies on atomic bomb survivors and related issues Chair: James E. Trosko, Michigan State University, East Lansing, MI, USA and Masahiro Nakashima, Nagasaki University, Nagasaki, Japan   Late hematological effects in the atomic bomb survivors   Kunihiro Tsukasaki, Nagasaki University, Nagasaki, Japan Long-term health consequences of atomic bomb radiation: RERF Life Span Study   Kazunori Kodama, Radiation Effects Research Foundation, Hiroshima, Japan Systematic collection of tissue specimens and molecular pathological analysis of newly diagnosed solid cancers among Atomic-bomb survivors   Wataru Yasui, Hiroshima University, Hiroshima, Japan Cancer risks analysis of low-dose radiation exposure   Peter W. Chang, National Yangming University, Taiwan   18:30-20:30 Reception Day 2 (27 July 2006) 9:30-12:10 Radiation biology Chair: Fumio Suzuki, Hiroshima University, Hiroshima, Japan and Keiji Suzuki, Nagasaki University, Nagasaki, Japan   Concepts needed to understand potential health effects of chronic low level radiation exposures: role of adult cells and modulated cell-cell communication   James E. Trosko, Michigan State University, East Lansing, MI, USA Mechanism of radiation carcinogenesis: BigH3, COX-2 and beyond   Tom K. Hei, Columbia University, New York, NY, USA New insights on radiation-induced bystander signaling and its relationship to DNA repair   Kevin M. Prise, Gray Cancer Institute, Northwood, UK Targeted and non-targeted irradiations using an electron microbeam and their effects on radiation-induced genomic instability   William F. Morgan, University of Maryland, Baltimore, MD, USA Damage response of early embryonic development   Ohtsura Niwa, Kyoto University, Kyoto, Japan Telomere dysfunction in radiation-induced cancer   Robert Ullrich, Colorado State University, Fort Collins, CO, USA Secretory clusterin (sCLU) in a hallmark sensor of DNA damage, cell stress, and cellular senescence: evidence for similar regulation of sCLU after cellular stress and senescence   David A. Boothman, University of Texas, Dallas, TX, USA Human NBS1, MRE11 and ATM associate for regulation of checkpoint but not for homologous recombination repair   Kenshi Komatsu, Kyoto University, Kyoto, Japan   12:10-13:00 Lunch   13:00-14:20 Tissue bank and others Chair: Mykola D. Tronko, Institute of Endocrinology and Metabolism, Kiev, Ukraine and Hiroyuki Namba, Nagasaki University, Nagasaki, Japan   Establishment and function of the Chernobyl Tissue Bank   Geraldine A. Thomas, South West Wales Cancer Institute, Swansea, UK An overview of results arising from samples supplied by the Chernobyl Tissue Bank   Michael Tuttle, Memorial Sloan Kettering Cancer Center, New York, NY, USA Benefit and side effects of radioiodine therapy in radiation induced childhood thyroid carcinoma   Christoph Reiners, University of Würtzburg, Würtzburg, Germany Telemedical technologies in education. Experience of introduction and prospect of development at medical university of Gomel (Belarus)   Siargey V. Zhavaranak, Gomel Medical University, Gomel, Republic of Belarus   14:20-14:40 Coffee break   14:40-16:00 Radiation emergency Chair: Kenji Kamiya, Hiroshima University, Hiroshima and Akira Ohtsuru, Nagasaki University, Nagasaki, Japan   Acute radiation syndrome: a new look at its concept and current approach to medical management   Makoto Akashi, National Institute of Radiological Sciences, Chiba, Japan Education and training for radiation emergency medical management in Japan   Tatsuya Kinugasa, Nuclear Safety Research Association, Tokyo, Japan Reconstruction for local radiation injuries and proposed regeneration therapy for acute systemic radiation injuries   Sadanori Akita, Nagasaki University, Nagasaki, Japan Therapeutic angiogenesis by autologous transplantation of bone marrow mononuclear cells for peripheral artery disease   Kazuhiro Nagai, Nagasaki University, Nagasaki, Japan   16:00-16:30 COE program review Chair: Masao Tomonaga, Nagasaki University, Nagasaki, Japan Yasuhito Sasaki, International University of Health and Welfare, Otawara, Tochigi, Japan Masao Sasaki, Kyoto University, Kyoto, Japan Satellite Meeting Venue: Pompe van Meerdervoort Hall Nagasaki University School of Medicine 28 July 2006 09:00-12:00 Frontier techniques of radiation biology Chair: Shunichi Yamashita, World Health Organization, Geneva, Switzerland and Vladimir A. Saenko, Nagasaki University, Nagasaki, Japan   Usefulness of clinical application of rapid BRAF analysis: a progress report of the studies in Kazakhstan and Japan   Atsushi Kumagai, Nagasaki University, Nagasaki, Japan Characterization of side population in human thyroid cancer cell lines: trying to identify cancer stem cells   Norisato Mitsutake, Nagasaki University, Nagasaki, Japan Growth of IR-induced foci and G1 checkpoint   Motohiro Yamauchi, Nagasaki University, Nagasaki Japan GAGA factor promotes histone H3.3 replacement that prevents the heterochromatin spreading   Kenichi Nishioka, National Institute of Genetics, Mishima, Japan Telomere biology: implications for radiation carcinogenesis   Seiji Kodama, Osaka Prefecture University, Sakai, Osaka, Japan A trans-ethnic genomics study of DNA repair genes   Fumihiko Matsuda, Kyoto University, Kyoto, Japan   12:00-13:00 Lunch   13:00-16:50 Joint meeting with Pathology Panel 13:00-13:10   Introduction   Masahiro Ito, National Nagasaki Medical Center, Omura, Nagasaki, Japan     13:10-14:10 Thyroid Studies   Chair: Toshiyuki Nakayama, Nagasaki University, Nagasaki, Japan RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy   Masahiro Nakashima, Nagasaki University, Nagasaki, Japan Pathology of thyroid cancer in children and adolescents of Ukraine having been exposed as a result of the Chernobyl accident   Tetyana Bogdanova, Institute of Endocrinology and Metabolism, Kiev, Ukraine Immunoexpression of MUC1 in papillary thyroid carcinoma: an association with aberrant expression of β-catenin and cyclin D1 overexpression   Alexander Abrosimov, Medical Radiological Research Center of RAMS, Obninsk, Russian Federation     14:10-15:00 Special lecture   Chair: Masahiro Ito, National Nagasaki Medical Center, Omura, Nagasaki, Japan Chernobyl, radiation and thyroid cancer   Dillwyn Williams, Strangeways Research Laboratory, Cambridge, UK     15:00-15:20 Coffee break     15:20-16:50 Lectures by senior thyroid pathologists   Chair: Yuji Nagayama, Nagasaki University, Nagasaki, Japan Culture system for studying thyroid biology   Shuji Toda, Saga University, Saga, Japan Hashimoto's thyroiditis: Is it dysplasia?   Virginia A. LiVolsi, University of Pennsylvania, Philadelphia, PA, USA Mysteries in thyroid pathology   Ryohei Katoh, University of Yamanashi, Yamanashi, Japan