(1) Medical usage of radioisotope
Radioisotope (RI) and radiopharmaceuticals labeled with RI have character to distribute according to biological function in living tissue and are very useful for diagnostic imaging and therapeutic use. Our department develops and promotes medical use of RI for various conditions such as cardiac, neurological, oncological disorders and other illness, using the technology of positron emission tomography (PET) and single photon emission computed tomography (SPECT).
(2) Pre-clinical Molecular Imaging with small-animal PET/SPECT/CT
Molecular imaging is a non-invasive technique to visualize and quantify the vital function. In Nagasaki University, the small-animal PET/SPECT/CT system has introduced into BSL-3 laboratory.
We study about infectious disease, development of new drugs, and therapy evaluation by visualization of radiotracer disposition with PET/SPECT/CT and analysis of functional change in pathological animal models.
(3) Evaluation of measurement method of radioisotope inside living tissue
We are performing development and evaluation of quantitative measurement of minimal amount of radioisotope inside human body using whole body counter.
(4) Repair mechanisms of DNA damages by ionizing radiation
Ionizing radiation induces DNA double strand breaks (DSB). DSB are repaired by homologous repair (HR) and non-homologous end joining (NHEJ). Many reports describe other repair mechanisms. Double strand DNA dependent protein kinase (DNA-PK) plays an important role in NHEJ. DNA-PK activity is highly heat-sensitive. This leads to heat induced radiosensitization. Different radiosensitivity was observed in cells lacking different DNA-PK subunits. Using these cells, we are investigating the relationships of DSB repair mechanisms.