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研究業績(Selected Publications)
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研究室の業績 (学会発表、論文、著書他)


  1. Zha D, Yang Y, Huang X, Wang Z, Lin H, Yang L, Xu L, Wu Y, Huang H, Wang Y, Xin Z, Wu X, Xiao YF, Li TS, Deng KY, Xin HB, Qian Y.
    Nicaraven protects against endotoxemia-induced inflammation and organ injury through modulation of AMPK/Sirt1 signaling in macrophages
    Eur J Pharmacol. 2023 May 5;946:175666. doi: 10.1016/j.ejphar.2023.175666. Epub 2023 Mar 20. PMID: 36944380
    [ PubMed ]
  2. Vargas JNS, Hamasaki M, Kawabata T, Youle RJ, Yoshimori T.
    The mechanisms and roles of selective autophagy in mammals.
    Nat Rev Mol Cell Biol. 2023 Mar;24(3):167-185. doi: 10.1038/s41580-022-00542-2. Epub 2022 Oct 27. PMID: 36302887
    [ PubMed ]

  1. Abdelghany L , Kawabata T, Goto D, Jingu K, Li TS
    Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly(ADP-ribose) glycohydrolase in cancercells
    Transl Oncol. 2022 Oct 4;26:101548. doi: 10.1016/j.tranon.2022.101548. Online ahead of print. PMID: 36206675 Free PMC article.
    [ PubMed ]
  2. Xu Y, Abdelghany L, Sekiya R, Zhai D, Jingu K,  Li TS
    Optimization on the dose and time of nicaraven administration for mitigating the side effects of radiotherapy in a preclinical tumor-bearing mouse model
    Ther Adv Respir Dis. 2022 Jan-Dec;16:17534666221137277. doi:10.1177/17534666221137277. PMID: 36404753 Free PMC article.
    [ PubMed ]
  3. Zhang G, Liu Z, Deng J, Liu L, Li Y, Weng S, Guo C, Zhou Z, Zhang L, Wang X, Liu G, Guo J, Bai J, Wang Y, Du Y, Li TS, Tang J, Zhang J.
    Smooth muscle cell fate decisions decipher a high-resolution heterogeneity within atherosclerosis molecular subtypes
    J Transl Med. 2022 Dec 6;20(1):568. doi: 10.1186/s12967-022-03795-9. PMID: 36474294 Free PMC article.
    [ PubMed ]
  4. Nie H, Yan C, Zhou W, Li TS.
    Analysis of Immune and Inflammation Characteristics of Atherosclerosis from Different Sample Sources.
    Oxid Med Cell Longev. 2022 Apr 25;2022:5491038. doi: 10.1155/2022/5491038. eCollection 2022. PMID: 35509837 Free PMC article.
    [ PubMed ]
  5. Yamamuro T, Nakamura S, Yanagawa K, Tokumura A, Kawabata T, Fukuhara A, Teranishi H, Hamasaki M, Shimomura I, Yoshimori T.
    Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response.
    Autophagy. 2022 Mar 14:1-11. doi: 10.1080/15548627.2022.2047341. Online ahead of print. PMID: 35282767
    [ PubMed ]
  6. Huang Z, Khalifa MO, Gu W, Li TS.
    Hydrostatic pressure induces profibrotic properties in hepatic stellate cells via the RhoA/ROCK signaling pathway.
    FEBS Open Bio. 2022 Mar 31. doi: 10.1002/2211-5463.13405. Online ahead of print. PMID: 35357779 Free article.
    [ PubMed ]
  7. Ohashi K, Li TS, Miura S, Hasegawa Y, Miura K.
    Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells.
    Anticancer Res. 2022 Apr;42(4):1729-1737. doi: 10.21873/anticanres.15649. PMID: 35346991
    [ PubMed ]
  8. Zhang X, Yassouf Y, Huang K, Xu Y, Huang ZS, Zhai D, Sekiya R, Liu KX, Li TS.
    Ex Vivo Hydrostatic Pressure Loading of Atrial Tissues Activates Profibrotic Transcription via TGF-β Signal Pathway.
    Int Heart J. 2022 Mar 30;63(2):367-374. doi: 10.1536/ihj.21-481. Epub 2022 Mar 15. PMID: 35296614 Free article.
    [ PubMed ]
  9. Huang Z, Khalifa MO, Li P, Huang Y, Gu W, Li TS.
    Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells.
    Am J Physiol Gastrointest Liver Physiol. 2022 Apr 1;322(4):G446-G456. doi: 10.1152/ajpgi.00238.2021. Epub 2022 Feb 9. PMID: 35138187
    [ PubMed ]
  10. Xu Y, Zhai D, Goto S, Zhang X, Jingu K, Li TS.
    Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response.
    J Radiat Res. 2022 Mar 17;63(2):158-165. doi: 10.1093/jrr/rrab112. PMID: 34999842 Free PMC article.
    [ PubMed ]
  11. Yassouf MY, Zhang X, Huang Z, Zhai D, Sekiya R, Kawabata T, Li TS.
    Biphasic effect of mechanical stress on lymphocyte activation.
    J Cell Physiol. 2022 Feb;237(2):1521-1531. doi: 10.1002/jcp.30623. Epub 2021 Nov 1. PMID: 34724217
    [ PubMed ]
  12. Yoshida G, Kawabata T, Takamatsu H, Saita S, Nakamura S, Nishikawa K, Fujiwara M, Enokidani Y, Yamamuro T, Tabata K, Hamasaki M, Ishii M, Kumanogoh A, Yoshimori T.
    Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis.
    Autophagy. 2022 Jan 13:1-10. doi: 10.1080/15548627.2021.2017587. Online ahead of print. PMID: 35025696
    [ PubMed ]
  13. Khalifa MO, Abd-Elkareem M, Gaber W, Li TS, Saleh AM.
    Developmental morphological analyses on the preglottal salivary gland in Japanese quails (Coturnix japonica).
    Microsc Res Tech. 2022 Jan;85(1):156-168. doi: 10.1002/jemt.23892. Epub 2021 Aug 3. PMID: 34343385
    [ PubMed ]

  1. Abdelghany L, Zhang X, Kawabata T, Goto S, El-Mahdy N, Jingu K, Li TS.
    Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism.
    Med Oncol. 2021 Nov 10;39(1):7. doi: 10.1007/s12032-021-01602-x. PMID: 34761342
    [ PubMed ]
  2. Zhang S, Sharaf Eldin HE, Gu WL, Li TS.
    Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.
    Am J Transl Res. 2021 Nov 15;13(11):12684-12693. eCollection 2021. PMID: 34956483 Free PMC article.
    [ PubMed ]
  3. Zhai D, Xu Y, Abdelghany L, Zhang X, Liang J, Zhang S, Guo C, Li TS.
    Hydrostatic pressure stabilizes HIF‑1α expression in cancer cells to protect against oxidative damage during metastasis.
    Oncol Rep. 2021 Oct;46(4):211. doi: 10.3892/or.2021.8162. Epub 2021 Aug 9. PMID: 34368876
    [ PubMed ]
  4. Li Y, Luo NC, Zhang X, Hara T, Inadomi C, Li TS.
    Prolonged oxygen exposure causes the mobilization and functional damage of stem or progenitor cells and exacerbates cardiac ischemia or reperfusion injury in healthy mice.
    J Cell Physiol. 2021 Sep;236(9):6657-6665. doi: 10.1002/jcp.30317. Epub 2021 Feb 7. PMID: 33554327
    [ PubMed ]
  5. Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T.
    Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
    PLoS Genet. 2021 Aug 5;17(8):e1009688. doi: 10.1371/journal.pgen.1009688. eCollection 2021 Aug. PMID: 34351902 Free PMC article.
    [ PubMed ]
  6. Yang L, Deng J, Ma W, Qiao A, Xu S, Yu Y, Boriboun C, Kang X, Han D, Ernst P, Zhou L, Shi J, Zhang E, Li TS, Qiu H, Nakagawa S, Blackshaw S, Zhang J, Qin G.
    Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure.
    Theranostics. 2021 Jul 6;11(16):7995-8007. doi: 10.7150/thno.50990. eCollection 2021. PMID: 34335976 Free PMC article.
    [ PubMed ]
  7. Luo L, Yan C, Fuchi N, Kodama Y, Zhang X, Shinji G, Miura K, Sasaki H, Li TS.
    Mesenchymal stem cell-derived extracellular vesicles as probable triggers of radiation-induced heart disease.
    Stem Cell Res Ther. 2021 Jul 22;12(1):422. doi: 10.1186/s13287-021-02504-5. PMID: 34294160 Free PMC article.
    [ PubMed ]
  8. Abdelghany L, El-Mahdy N, Kawabata T, Goto S, Li TS.
    Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation.
    Oncol Lett. 2021 Apr;21(4):251. doi: 10.3892/ol.2021.12512. Epub 2021 Feb 3. PMID: 33664815 Free PMC article.
    [ PubMed ]
  9. Ando S, Hashida N, Yamashita D, Kawabata T, Asao K, Kawasaki S, Sakurai K, Yoshimori T, Nishida K.
    Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration.
    Biochem Biophys Res Commun. 2021 Apr 30;551:148-154. doi: 10.1016/j.bbrc.2021.02.148. Epub 2021 Mar 16. PMID: 33740621
    [ PubMed ]
  10. Wang KX, Cui WW, Yang X, Tao AB, Lan T, Li TS, Luo L.
    Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects.
    Cells. 2021 Feb 1;10(2):294. doi: 10.3390/cells10020294. PMID: 33535574 Free PMC article. Review.
    [ PubMed ]
  11. Wu JW, Zhang X, Sekiya R, Aoyagi K, Li TS.
    Immunohistochemical Analysis of Histone H3 Modification in Newt Tail Tissue Cells following Amputation.
    Stem Cells Int. 2021 Jan 5;2021:8828931. doi: 10.1155/2021/8828931. eCollection 2021. PMID: 33505473 Free PMC article.
    [ PubMed ]
  12. Hasan AS, Luo L, Baba S, Li TS.
    Estrogen is required for maintaining the quality of cardiac stem cells.
    PLoS One. 2021 Jan 22;16(1):e0245166. doi: 10.1371/journal.pone.0245166. eCollection 2021. PMID: 33481861 Free PMC article.
    [ PubMed ]

  1. 「Fetal Morph Functional Dignosis」
    Chapter15  Sex Chromosome-Linked Diseases
    Haibo Li,Lulu Yan,Yuxin Zhang,Yingwen Liu,Min Xie,Ning Song and Taosheng Li
    First Online: 06 December 2020

  1. Zhang X, Li TS.
    ASO Author Reflections: How Should a Surgeon Care and Manage Cancer Metastasis? Ann Surg Oncol. 2020 Apr;27(4):1075-1076. doi: 10.1245/s10434-019-08131-y. Epub 2019 Dec 12. PMID: 31832918
  2. Luo L, Li TS.
    Mini review: Recent advances in the cell-based therapies for cardiac regeneration.
    Curr Stem Cell Res Ther. 2020 Jan 1. doi: 10.2174/1574888X15666200102103755
    [ PubMed ]
  3. Zhang X, Moriwaki T, Kawabata T, Goto S, Liu KX, Guo CY, Li TS.
    Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis.
    Ann Surg Oncol. 2020 Apr;27(4):1068-1074. doi: 10.1245/s10434-019-08076-2. Epub 2019 Dec 23. PMID: 31873930.
    [ PubMed ]
  4. Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T.Unno R,
    Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
    Autophagy. 2020 Apr;16(4):709-723. doi: 10.1080/15548627.2019.1635382. Epub 2019 Jun 29.Autophagy. 2020. PMID: 31257986 Free PMC article.
    [ PubMed ]
  5. Kawabata T, Yoshimori T
    Autophagosome biogenesis and human health.
    2020 Jun 2;6:33. doi: 10.1038/s41421-020-0166-y. eCollection 2020.Cell Discov. 2020. PMID: 32528724 Free PMC article. Review.
    [ PubMed ]
  6. Goto S, Kawabata T, Li TS.
    Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance.
    2020 Aug 12;2020:8868849. doi: 10.1155/2020/8868849. eCollection 2020.Stem Cells Int. 2020. PMID: 32849878 Free PMC article.
    [ PubMed ]
  7. Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, Hamasaki M, Kuma A, Yamamoto K, Shimomura I, Yoshimori T.Yamamuro T,
    Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
    2020 Aug 18;11(1):4150. doi: 10.1038/s41467-020-17985-w.Nat Commun. 2020. PMID: 32811819 Free PMC article.
    [ PubMed ]

  1. Yang L, Yan F, Ma J, Zhang J, Liu L, Guan L, Zheng H, Li T, Liang D, Mu Y.
    Ultrasound-Targeted Microbubble Destruction-Mediated Co-Delivery of Cxcl12 (Sdf-1alpha) and Bmp2 Genes for Myocardial Repair.
    J Biomed Nanotechnol. 2019 Jun 1;15(6):1299-1312. doi: 10.1166/jbn.2019.2776.
    [ PubMed ]
  2. Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T.
    Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
    Autophagy. 2019 Jun 29:1-15. doi: 10.1080/15548627.2019.1635382.
    [Epub ahead of print]
    [ PubMed ]
  3. Peng YH, Xiao J, Yan C, Luo L, Li TS.
    Potential Role of the Resident Mesenchymal Stem-Like Cells in Renal Fibrogenesis after Ureteral Obstruction.
    Stem Cells Int. 2019 Mar 5;2019:2543171. doi: 10.1155/2019/2543171. eCollection 2019.
    [ PubMed ]
  4. Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T.
    Suppression of autophagic activity by Rubicon is a signature of aging.
    Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6.
    [ PubMed ]
  5. El-Sayed M, El-Feky MA, El-Amir MI, Hasan AS, Tag-Adeen M, Urata Y, Goto S, Luo L, Yan C, Li TS.
    Immunomodulatory effect of mesenchymal stem cells: Cell origin and cell quality variations.
    Mol Biol Rep. 2019 Jan 9. doi: 10.1007/s11033-018-04582-w.
    [ PubMed ]
  6. Song Y, Zhao M, Xie Y, Zhu T, Liang W, Sun B, Liu W, Wu L, Lu G, Li TS, Yin T, Xie Y.
    Bmi-1 high-expressing cells enrich cardiac stem/progenitor cells and respond to heart injury.
    J Cell Mol Med. 2019 Jan;23(1):104-111. doi: 10.1111/jcmm.13889. Epub 2018 Nov 5.
    [ PubMed ]
  7. Zhou M, Yoshikawa K, Akashi H, Miura M, Suzuki R, Li TS, Abe H, Bando Y.
    Localization of ATP-sensitive K+ channel subunits in rat liver.
    World J Exp Med. 2019 Dec 19;9(2):14-31. doi: 10.5493/wjem.v9.i2.14. eCollection 2019 Dec 19. PMID: 31938690
    [ PubMed ]

  1. Peng YH, Yu XM, Yan C, Luo L, Li TS, Xiao J.
    Recovery of renal function in a heart transplantation recipient with over 300 days of iatrogenic anuria: A case report.
    Medicine (Baltimore). 2018 Apr;97(17):e0451. doi: 10.1097/MD.0000000000010451.
    [ PubMed ]
  2. Tang JN, Cores J, Huang K, Cui XL, Luo L, Zhang JY, Li TS, Qian L, Cheng K.
    Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future.
    Stem Cells Transl Med. 2018 Apr;7(4):354-359. doi: 10.1002/sctm.17-0196. Epub 2018 Feb 22. Review.
    [ PubMed ]
  3. Yano R, Inadomi C, Luo L, Goto S, Hara T, Li TS.
    The effect of transient oxygenation on stem cell mobilization and ischemia/reperfusion heart injury.
    PLoS One. 2018 Feb 13;13(2):e0192733. doi: 10.1371/journal.pone.0192733. eCollection 2018.
    [ PubMed ]
  4. Yan C, Li TS.
    Dual Role of Mitophagy in Cancer Drug Resistance.
    Anticancer Res. 2018 Feb;38(2):617-621. Review.
    [ PubMed ]
  5. Kurashima K, Sekimoto T, Oda T, Kawabata T, Hanaoka F, Yamashita T.
    Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress.
    J Cell Sci. 2018 Jun 25;131(12). pii: jcs212183. doi: 10.1242/jcs.212183.
    [ PubMed ]
  6. Yan C, Luo L, Urata Y, Goto S, Li TS.
    Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment.
    Cancer Lett. 2018 Apr 1;418:204-210. doi: 10.1016/j.canlet.2018.01.037. Epub 2018 Jan 13.
    [ PubMed ]

  1. 川端剛、吉森保
    臨床免疫・アレルギー科   70(5) 532-536   2018年11月
  2. 川端剛
    臨床免疫・アレルギー科   70(5) 429-436   2018年11月
  3. 川端剛、吉森保
    日本産婦人科医会研修ノート   101 44-46   2018年8月

  1. 「オートファジー 分子メカニズムの理解から病態の解明まで」
    川端剛、吉森保 (担当:分担執筆, 範囲:オートファジーと癌 p188~197)
    南山堂 2018年1月

  1. Fuchi N, Miura K, Doi H, Li TS, Masuzaki H.
    Corrigendum: Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.
    Sci Rep. 2017 Dec 22;7:46922. doi: 10.1038/srep46922.
    [ PubMed ]
  2. Fuchi N, Miura K, Doi H, Li TS, Masuzaki H.
    Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.
    Sci Rep. 2017 Apr 12;7:46220. doi: 10.1038/srep46220.
    [ PubMed ]
  3. Luo L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li TS, Cheng K. Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice.
    Circ Res. 2017 May 26;120(11):1768-1775. doi: 10.1161/CIRCRESAHA.116.310374.
    [ PubMed ]
  4. Guo CY, Yan C, Luo L, Goto S, Urata Y, Xu JJ, Wen XM, Kuang YK, Tou FF, Li TS. Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.
    Oncol Rep. 2017 Apr;37(4):2161-2166. doi: 10.3892/or.2017.5438.
    [ PubMed ]
  5. Yan C, Luo L, Urata Y, Goto S, Guo CY, Li TS.
    Nicaraven, a potential radioprotective agent, has very limited effects on the survival of cancer cells and the growth of established tumors.
    Radiat Res. 2017 Mar;187(3):339-345. doi: 10.1667/RR4614.1.
    [ PubMed ]
  6. Lu SL, Kawabata T, Cheng YL, Omori H, Hamasaki M, Kusaba T, Iwamoto R, Arimoto H, Noda T, Lin YS, Yoshimori T.
    Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes.
    PLoS Pathog. 2017 Jul 6;13(7):e1006444. doi: 10.1371/journal.ppat.1006444.
    [ PubMed ]
  7. Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS.
    Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice.
    Sci Rep. 2017 Jan 18;7:40959. doi: 10.1038/srep40959.
    [ PubMed ]
  8. Tang J, Shen D, Caranasos TG, Wang Z, Vandergriff AC, Allen TA, Hensley MT, Dinh PU, Cores J, Li TS, Zhang J, Kan Q, Cheng K.
    Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.
    Nat Commun. 2017 Jan 3;8:13724. doi: 10.1038/ncomms13724.
    [ PubMed ]
  9. Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS.
    Ionizing Radiation Impairs Endogenous Regeneration of Infarcted Heart: An In Vivo 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT/CT Study in Mice.
    Radiat Res. 2017 Jan;187(1):89-97. doi: 10.1667/RR14543.1.
    [ PubMed ]
  10. Yan C, Luo L, Guo CY, Goto S, Urata Y, Shao JH, Li TS.
    Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells.
    Cancer Lett. 2016 Nov 30;388:34-42. doi: 10.1016/j.canlet.2016.11.018. [Epub ahead of print]
    [ PubMed ]

  1. Kawabata T, Yoshimori T.
    Beyond starvation: An update on the autophagic machinery and its functions.
    J Mol Cell Cardiol. 2016 Jun;95:2-10. doi: 10.1016/j.yjmcc.2015.12.005.
     [ PubMed ]
  2. Hasan AS, Luo L, Yan C, Zhang TX, Urata Y, Goto S, Mangoura SA, Abdel-Raheem MH, Zhang S, Li TS.
    Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment.
    PLoS One. 2016 Oct 20;11(10):e0165255. doi: 10.1371/journal.pone.0165255. Erratum in: PLoS One. 2017 Feb 6;12 (2):e0171892.
    [ PubMed ]
  3. Long J, Guo H, Cui S, Zhang H, Liu X, Li D, Han Z, Xi L, Kou W, Xu J, Li TS, Ding Y.
    IL-35 expression in hepatocellular carcinoma cells is associated with tumor progression.
    Oncotarget. 2016 Jul 19;7(29):45678-45686. doi: 10.18632/oncotarget.10141.
    [ PubMed ]
  4. Shen D, Tang J, Hensley MT, Li T, Caranasos TG, Zhang T, Zhang J, Cheng K.
    Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair.
    Stem Cells Transl Med. 2016 Jun;5(6):793-803. doi: 10.5966/sctm.2015-0194.
    [ PubMed ]
  5. Zhang S, Li TS, Soyama A, Tanaka T, Yan C, Sakai Y, Hidaka M, Kinoshita A, Natsuda K, Fujii M, Kugiyama T, Baimakhanov Z, Kuroki T, Gu W, Eguchi S.
    Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver.
    Sci Rep. 2016 May 26;6:26540. doi: 10.1038/srep26540.
    [ PubMed ]
  6. Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
    Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice.
    PLoS One. 2016 May 19;11(5):e0152179. doi: 10.1371/journal.pone.0152179.
    [ PubMed ]
  7. Yan C, Luo L, Goto S, Urata Y, Guo CY, Doi H, Kitazato K, Li TS.
    Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance.
    Oncotarget. 2016 Jul 19;7(29):45112-45121. doi: 10.18632/oncotarget.8972.
    [ PubMed ]
  8. Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, Ueno K, Nishimoto A, Kurazumi H, Suzuki R, Ito H, Sakata K, Mikamo A, Li TS, Hamano K.
    Influence of aging on the quantity and quality of human cardiac stem cells.
    Sci Rep. 2016 Mar 7;6:22781. doi: 10.1038/srep22781.
    [ PubMed ]
  9. Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS.
    Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
    Sci Rep. 2016 Jan 5;6:18844. doi: 10.1038/srep18844.
    [ PubMed ]
  10. Seko D, Ogawa S, Li TS, Taimura A, Ono Y.
    μ-Crystallin controls muscle function through thyroid hormone action.
    FASEB J. 2016 May;30(5):1733-40. doi: 10.1096/fj.15-280933.
    [ PubMed ]

  1. Hosoyama T, Samura M, Kudo T, Nishimoto A, Ueno K, Murata T, Ohama T, Sato K, Mikamo A, Yoshimura K, Li TS, Hamano K.
    Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart.
    Am J Transl Res. 2015 Dec 15;7(12):2738-51.
    [ PubMed ]
  2. Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.
    XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.
    J Allergy Clin Immunol. 2015 Oct;136(4):1007-17. doi: 10.1016/j.jaci.2015.06.007.
    [ PubMed ]
  3. Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS, Masuzaki H.
    Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.
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    Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells.
    Physiol Rep. 2015 Apr;3(4). pii: e12377. doi: 10.14814/phy2.12377.
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    Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.
    J Cell Mol Med. 2015 Aug;19(8):1805-13. doi: 10.1111/jcmm.12585.
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    Muscle stem cell fate is controlled by the cell-polarity protein Scrib.
    Cell Rep. 2015 Feb 24;10(7):1135-48. doi: 10.1016/j.celrep.2015.01.045.
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    The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells.
    J Cell Mol Med. 2015 Jul;19(7):1569-81. doi: 10.1111/jcmm.12531.
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    Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice.
    Sci Rep. 2015 Jan 27;5:8055. doi: 10.1038/srep08055.
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  9. Tanaka T, Li TS, Urata Y, Goto S, Ono Y, Kawakatsu M, Matsushima H, Hirabaru M, Adachi T, Kitasato A, Takatsuki M, Kuroki T, Eguchi S.
    Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2015 Sep;50(9):975-83. doi: 10.1007/s00535-014-1030-3.
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  1. Luebben SW*, Kawabata T*(*equal contribution), Johnson CS, O'Sullivan MG, Shima N.
    A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.
    Nucleic Acids Res. 2014 May;42(9):5605-15. doi: 10.1093/nar/gku170. 
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    Enhanced Nox1 expression and oxidative stress resistance in c-kit-positive hematopoietic stem/progenitor cells.
    Biochem Biophys Res Commun. 2014 Nov 21;454(3):376-80. doi:10.1016/j.bbrc.2014.10.090.
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  3. Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS.
    The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.
    Biochem Biophys Res Commun. 2014 Sep 26;452(3):548-53. doi:10.1016/j.bbrc.2014.08.112.
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    Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells. 
    Stem Cells. 2014 Sep;32(9):2397-406. doi: 10.1002/stem.1736.
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  5. Nishimoto A, Kugimiya N, Hosoyama T, Enoki T, Li TS, Hamano K.
    HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells.
    Int J Oncol. 2014 Jun;44(6):2077-84. doi: 10.3892/ijo.2014.2367.
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  6. Cheng K, Malliaras K, Smith RR, Shen D, Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E.
    Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.
    JACC Heart Fail. 2014 Feb;2(1):49-61.
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  7. Kudo T, Hosoyama T, Samura M, Katsura S, Nishimoto A, Kugimiya N, Fujii Y, Li TS, Hamano K.
    Hypoxic preconditioning reinforces cellular functions of autologous peripheral blood-derived cells in rabbit hindlimb ischemia model.
    Biochem Biophys Res Commun. 2014 Feb 14;444(3):370-5. doi:10.1016/j.bbrc.2014.01.054.
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  8. Kurazumi H, Li TS, Takemoto Y, Suzuki R, Mikamo A, Guo CY, Murata T, Hamano K.
    Haemodynamic unloading increases the survival and affects the differentiation of cardiac stem cells after implantation into an infarcted heart.
    Eur J Cardiothorac Surg. 2014 Jun;45(6):976-82. doi: 10.1093/ejcts/ezt629.
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  9. Luo L, Kawakatsu M, Guo CW, Urata Y, Huang WJ, Ali H, Doi H, Kitajima Y, Tanaka T, Goto S, Ono Y, Xin HB, Hamano K, Li TS.
    Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells.
    Sci Rep. 2014 Jan 21;4:3779. doi: 10.1038/srep03779.
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  1. Nishimoto A, Kugimiya N, Hosoyama T, Enoki T, Li TS, Hamano K.
    JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells.
    Biochem Biophys Res Commun. 2013 Aug 30;438(3):513-8. doi:10.1016/j.bbrc.2013.07.105.
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  2. Kashiyama K, Nakazawa Y, Pilz DT, Guo C, Shimada M, Sasaki K, Fawcett H, Wing JF, Lewin SO, Carr L, Li TS, Yoshiura K, Utani A, Hirano A, Yamashita S, Greenblatt D, Nardo T, Stefanini M, McGibbon D, Sarkany R, Fassihi H, Takahashi Y, Nagayama Y, Mitsutake N, Lehmann AR, Ogi T.
    Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia.
    Am J Hum Genet. 2013 May 2;92(5):807-19. doi: 10.1016/j.ajhg.2013.04.007.
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  3. Guo CW, Kawakatsu M, Idemitsu M, Urata Y, Goto S, Ono Y, Hamano K, Li TS.
    Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells.
    J Cell Physiol. 2013 Nov;228(11):2159-66. doi: 10.1002/jcp.24389.
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  4. Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS.
    Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice.
    PLoS One. 2013;8(3):e60023. doi: 10.1371/journal.pone.0060023.
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  5. Suga A, Ueda K, Takemoto Y, Nishimoto A, Hosoyama T, Li TS, Hamano K.
    Significant role of bone marrow-derived cells in compensatory regenerative lung growth.
    J Surg Res. 2013 Jul;183(1):84-90. doi: 10.1016/j.jss.2012.12.013.
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  6. Takemoto Y, Li TS, Kubo M, Ohshima M, Kurazumi H, Ueda K, Enoki T, Murata T, Hamano K.
    The mobilization and recruitment of c-kit+ cells contribute to wound healing after surgery.
    PLoS One. 2012;7(11):e48052. doi: 10.1371/journal.pone.0048052.
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  7. Kawakatsu M, Urata Y, Goto S, Ono Y, Li TS.
    Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity.
    J Radiat Res. 2013 Mar 1;54(2):268-76. doi: 10.1093/jrr/rrs105.
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  8. Ueda K, Tanaka T, Hayashi M, Tanaka N, Li TS, Hamano K.
    Right middle lobe transposition after upper lobectomy: influence on postoperative pulmonary function.
    Thorac Cardiovasc Surg. 2013 Mar;61(2):138-43. doi: 10.1055/s-0032-1311531.
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  9. Nakamoto M, Hirose M, Kawakatsu M, Nakayama T, Urata Y, Kamata K, Kaminogo M, Li TS, Nagata I.
    Serum S-glutathionylated proteins as a potential biomarker of carotid artery stenosis.
    Clin Biochem. 2012 Nov;45(16-17):1331-5. doi: 10.1016/j.clinbiochem.2012.06.017.
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  1. Kubo M, Li TS, Kurazumi H, Takemoto Y, Ohshima M, Yamamoto Y, Nishimoto A, Mikamo A, Fujimoto M, Nakai A, Hamano K.
    Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells.
    PLoS One. 2012;7(5):e37934. doi: 10.1371/journal.pone.0037934.
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  2. Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L.
    Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel.
    Biomaterials. 2012 Jul;33(21):5317-24. doi: 10.1016/j.biomaterials.2012.04.006.
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  3. Ueda K, Tanaka T, Hayashi M, Li TS, Hamano K.
    Verification of early removal of the chest tube after absorbable mesh-based pneumostasis subsequent to video-assisted major lung resection for cancer.
    World J Surg. 2012 Jul;36(7):1603-7. doi: 10.1007/s00268-012-1557-5.
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  4. Cheng K, Malliaras K, Li TS, Sun B, Houde C, Galang G, Smith J, Matsushita N, Marbán E.
    Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.
    Cell Transplant. 2012;21(6):1121-35. doi: 10.3727/096368911X627381.
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  5. Barth AS, Zhang Y, Li T, Smith RR, Chimenti I, Terrovitis I, Davis DR, Kizana E, Ho AS, O'Rourke B, Wolff AC, Gerstenblith G, Marbán E.
    Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab.
    Stem Cells Transl Med. 2012 Apr;1(4):289-97. doi: 10.5966/sctm.2011-0016.
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  6. Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marbán L, Marbán E.
    Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.
    J Am Coll Cardiol. 2012 Mar 6;59(10):942-53. doi: 10.1016/j.jacc.2011.11.029.
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  7. Kubo M, Li TS, Kurazumi H, Takemoto Y, Ohshima M, Murata T, Katsura S, Morikage N, Furutani A, Hamano K.
    Hypoxic preconditioning enhances angiogenic potential of bone marrow cells with aging-related functional impairment.
    Circ J. 2012;76(4):986-94.
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  1. Kawabata T, Yamaguchi S, Buske T, Luebben SW, Wallace M, Matise I, Schimenti JC, Shima N.
    A reduction of licensed origins reveals strain-specific replication dynamics in mice.
    Mamm Genome. 2011 Oct;22(9-10):506-17. doi: 10.1007/s00335-011-9333-7.
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  2. Kawabata T, Luebben SW, Yamaguchi S, Ilves I, Matise I, Buske T, Botchan MR, Shima N. Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.
    Mol Cell. 2011 Mar 4;41(5):543-53. doi: 10.1016/j.molcel.2011.02.006.
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  3. Kurazumi H, Kubo M, Ohshima M, Yamamoto Y, Takemoto Y, Suzuki R, Ikenaga S, Mikamo A, Udo K, Hamano K, Li TS.
    The effects of mechanical stress on the growth, differentiation, and paracrine factor production of cardiac stem cells.
    PLoS One. 2011;6(12):e28890. doi: 10.1371/journal.pone.0028890.
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  4. Yoshida T, Goto S, Kawakatsu M, Urata Y, Li TS.
    Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation.
    Free Radic Res. 2012 Feb;46(2):147-53. doi: 10.3109/10715762.2011.645207.
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  5. Ueda K, Tanaka T, Hayashi M, Tanaka N, Li TS, Hamano K.
    Clinical ramifications of bronchial kink after upper lobectomy.
    Ann Thorac Surg. 2012 Jan;93(1):259-65. doi: 10.1016/j.athoracsur.2011.08.065.
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  6. Malliaras K, Li TS, Luthringer D, Terrovitis J, Cheng K, Chakravarty T, Galang G, Zhang Y, Schoenhoff F, Van Eyk J, Marbán L, Marbán E.
    Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells.
    Circulation. 2012 Jan 3;125(1):100-12. doi: 10.1161/CIRCULATIONAHA.111.042598.
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  7. Li TS, Ikeda S, Kubo M, Ohshima M, Kurazumi H, Takemoto Y, Ueda K, Hamano K.
    Diabetic impairment of C-kit bone marrow stem cells involves the disorders of inflammatory factors, cell adhesion and extracellular matrix molecules.
    PLoS One. 2011;6(10):e25543. doi: 10.1371/journal.pone.0025543.
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  8. Kawakatsu M, Goto S, Yoshida T, Urata Y, Li TS.
    Nuclear translocation of glutathione S-transferase π is mediated by a non-classical localization signal.
    Biochem Biophys Res Commun. 2011 Aug 12;411(4):745-50. doi: 10.1016/j.bbrc.2011.07.018.
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  9. Ueda K, Tanaka T, Hayashi M, Tanaka N, Li TS, Hamano K.
    What proportion of lung cancers can be operated by segmentectomy? A computed-tomography-based simulation.
    Eur J Cardiothorac Surg. 2012 Feb;41(2):341-5. doi: 10.1016/j.ejcts.2011.05.034.
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  10. Ueda K, Tanaka T, Hayashi M, Li TS, Kaneoka T, Tanaka N, Hamano K.
    Compensation of pulmonary function after upper lobectomy versus lower lobectomy.
    J Thorac Cardiovasc Surg. 2011 Oct;142(4):762-7. doi: 10.1016/j.jtcvs.2011.04.037.
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  11. Takemoto Y, Li TS, Kubo M, Ohshima M, Ueda K, Harada E, Enoki T, Okamoto M, Mizukami Y, Murata T, Hamano K.
    Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells.
    Surgery. 2011 Jun;149(6):792-800. doi: 10.1016/j.surg.2011.02.005.
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  12. Lee ST, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li TS, Terrovitis J, Yee K, Simsir S, Makkar R, Marbán E.
    Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction.
    J Am Coll Cardiol. 2011 Jan 25;57(4):455-65. doi: 10.1016/j.jacc.2010.07.049.
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  1. Li TS, Cheng K, Lee ST, Matsushita S, Davis D, Malliaras K, Zhang Y, Matsushita N, Smith RR, Marbán E.
    Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair.
    Stem Cells. 2010 Nov;28(11):2088-98. doi: 10.1002/stem.532.
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  2. Zhang Y, Li TS, Lee ST, Wawrowsky KA, Cheng K, Galang G, Malliaras K, Abraham MR, Wang C, Marbán E.
    Dedifferentiation and proliferation of mammalian cardiomyocytes.
    PLoS One. 2010 Sep 3;5(9):e12559. doi: 10.1371/journal.pone.0012559.
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  3. Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marbán L, Zhang Y, Marbán E.
    Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
    Cardiovasc Res. 2011 Jan 1;89(1):157-65. doi: 10.1093/cvr/cvq251.
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  4. Kubo M, Li TS, Kamota T, Ohshima M, Shirasawa B, Hamano K.
    Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis.
    J Vasc Surg. 2010 Aug;52(2):429-34. doi: 10.1016/j.jvs.2010.03.017.
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  5. Li TS, Marbán E.
    Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells.
    Stem Cells. 2010 Jul;28(7):1178-85. doi: 10.1002/stem.438.
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  6. Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marbán E.
    Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction.
    Circ Res. 2010 May 28;106(10):1570-81. doi: 10.1161/CIRCRESAHA.109.212589.
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  7. Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marbán E.
    Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.
    Circ Res. 2010 Mar 19;106(5):971-80. doi: 10.1161/CIRCRESAHA.109.210682.
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  8. Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marbán E.
    Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue.
    PLoS One. 2009 Sep 25;4(9):e7195. doi: 10.1371/journal.pone.0007195.
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  9. Li TS, Kubo M, Ueda K, Murakami M, Ohshima M, Kobayashi T, Tanaka T, Shirasawa B, Mikamo A, Hamano K.
    Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients.
    Circulation. 2009 Sep 15;120(11 Suppl):S255-61. doi: 10.1161/CIRCULATIONAHA.108.837039.
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  10. Li TS, Kubo M, Ueda K, Murakami M, Mikamo A, Hamano K.
    Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure.
    J Thorac Cardiovasc Surg. 2010 Feb;139(2):459-65. doi: 10.1016/j.jtcvs.2009.07.053.
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  11. Kamota T, Li TS, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Ikeda Y, Matsuzaki M, Hamano K.
    Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase.
    J Am Coll Cardiol. 2009 May 12;53(19):1814-22. doi: 10.1016/j.jacc.2009.02.015.
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  12. Kubo M, Li TS, Kamota T, Ohshima M, Qin SL, Hamano K.
    Increased expression of CXCR4 and integrin alphaM in hypoxia-preconditioned cells contributes to improved cell retention and angiogenic potency.
    J Cell Physiol. 2009 Aug;220(2):508-14. doi: 10.1002/jcp.21803.
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  13. Murakami J, Li TS, Ueda K, Tanaka T, Hamano K.
    Inhibition of accelerated tumor growth by blocking the recruitment of mobilized endothelial progenitor cells after chemotherapy.
    Int J Cancer. 2009 Apr 1;124(7):1685-92. doi: 10.1002/ijc.24085.
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  14. Li TS, Takahashi M, Ohshima M, Qin SL, Kubo M, Muramatsu K, Hamano K.
    Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells.
    Cell Transplant. 2008;17(6):695-703.
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  15. Li TS, Komota T, Ohshima M, Qin SL, Kubo M, Ueda K, Hamano K.
    TGF-beta induces the differentiation of bone marrow stem cells into immature cardiomyocytes.
    Biochem Biophys Res Commun. 2008 Feb 22;366(4):1074-80.
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  16. Kubo M, Li TS, Suzuki R, Shirasawa B, Morikage N, Ohshima M, Qin SL, Hamano K.
    Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance.
    Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H590-5.
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  17. Li TS, Murakami M, Kobayashi T, Shirasawa B, Mikamo A, Hamano K.
    Long-term efficacy and safety of the intramyocardial implantation of autologous bone marrow cells for the treatment of ischemic heart disease.
    J Thorac Cardiovasc Surg. 2007 Nov;134(5):1347-9. No abstract available.
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  18. Li TS, Mikamo A, Takahashi M, Suzuki R, Ueda K, Ikeda Y, Matsuzaki M, Hamano K.
    Comparison of cell therapy and cytokine therapy for functional repair in ischemic and nonischemic heart failure.
    Cell Transplant. 2007;16(4):365-74.
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  19. Suzuki R, Li TS, Mikamo A, Takahashi M, Ohshima M, Kubo M, Ito H, Hamano K.
    The reduction of hemodynamic loading assists self-regeneration of the injured heart by increasing cell proliferation, inhibiting cell apoptosis, and inducing stem-cell recruitment.
    J Thorac Cardiovasc Surg. 2007 Apr;133(4):1051-8.
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  20. Li TS, Suzuki R, Ueda K, Murata T, Hamano K.
    Analysis of the origin and population dynamics of cardiac progenitor cells in a donor heart model.
    Stem Cells. 2007 Apr;25(4):911-7.
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  21. Li TS, Takahashi M, Suzuki R, Kobayashi T, Ito H, Mikamo A, Hamano K.
    Pravastatin improves remodeling and cardiac function after myocardial infarction by an antiinflammatory mechanism rather than by the induction of angiogenesis.
    Ann Thorac Surg. 2006 Jun;81(6):2217-25.
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  22. Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, Ikeda Y, Matsuzaki M, Hamano K.
    Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury.
    Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H886-93.
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  23. Li TS, Furutani A, Takahashi M, Ohshima M, Qin SL, Kobayashi T, Ito H, Hamano K.
    Impaired potency of bone marrow mononuclear cells for inducing therapeutic angiogenesis in obese diabetic rats.
    Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1362-9.
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  24. Li TS, Hayashi M, Ito H, Furutani A, Murata T, Matsuzaki M, Hamano K.
    Regeneration of infarcted myocardium by intramyocardial implantation of ex vivo transforming growth factor-beta-preprogrammed bone marrow stem cells.
    Circulation. 2005 May 17;111(19):2438-45.
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  25. Li TS, Ito H, Hayashi M, Furutani A, Matsuzaki M, Hamano K.
    Cellular expression of integrin-beta 1 is of critical importance for inducing therapeutic angiogenesis by cell implantation.
    Cardiovasc Res. 2005 Jan 1;65(1):64-72.
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  26. Li TS, Hayashi M, Liu ZL, Ito H, Mikamo A, Furutani A, Matsuzaki M, Hamano K.
    Low angiogenic potency induced by the implantation of ex vivo expanded CD117(+) stem cells.
    Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1236-41.
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  27. Li TS, Ito H, Kajiwara K, Hamano K.
    Long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and CD40 blockade.
    Circulation. 2003 Oct 7;108(14):1760-5.
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  28. Li TS, Hamano K, Hirata K, Kobayashi T, Nishida M.
    The safety and feasibility of the local implantation of autologous bone marrow cells for ischemic heart disease.
    J Card Surg. 2003 Jul-Aug;18 Suppl 2:S69-75.
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  29. Li TS, Hamano K, Nishida M, Hayashi M, Ito H, Mikamo A, Matsuzaki M.
    CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation.
    Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H931-7.
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  30. Li TS, Hamano K, Suzuki K, Ito H, Zempo N, Matsuzaki M.
    Improved angiogenic potency by implantation of ex vivo hypoxia prestimulated bone marrow cells in rats.
    Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H468-73.
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