NAGASAKI UNIVERSITY GLOBAL COE PROGRAM - Global Strategic Center for Radiation Health Risk Control
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Global Strategic Center for Radiation Health Risk Control
The First International Symposium on
Establishment of a new discipline “Medical Care for Hibakusha”

In commemoration of Nagasaki University “Global Strategic Center for Radiation Health Risk Control” being selected as one of the winners of the “FY 2007 Global COE Program”, The First International Symposium on the Establishment of a New Discipline “Medical Care for Hibakusha” was held on January 31st and February 1st, 2008 at Matsumoto Ryojun Hall, Nagasaki University School of Medicine. The number of participants amounted to about 150, including guests, delegates from universities and institutes which have joined or are to join the consortium and domestic researchers inside and outside the university, and the symposium was led to success.

The opening ceremony of the symposium was commenced with the opening address by Dr. Hiroshi Saito, President of Nagasaki University, followed by addresses of four guests, Dr. Yoshiharu Yonekura (President, National Institute of Radiological Sciences), Dr. Toshiteru Okubo (Chairman, Radiation Effects Research Foundation), Dr. Kenzo Kiikuni (Chairman, Sasakawa Memorial Health Foundation), and Dr. Kenji Kamiya (President, The Japan Radiation Research Society) and ended with introduction to the COE program by Prof. Shunichi Yamashita of Project Leader. The first day of the symposium ended with the overview lectures given by Associate Prof. Takeshi Iimoto (Global COE, The University of Tokyo), Dr. Zhanat Carr (Scientist, WHO Headquarters), Prof. Kenji Kamiya (21st Century COE, Hiroshima University), Prof. Barry Michael (University of Oxford, Gray Cancer Institute), Prof. Geraldine Thomas (Hammersmith Hospital), and Prof. Michiaki Kai (Oita University of Nursing and Health Sciences). On the second day of the symposium, a total of 14 papers were presented at the three sessions of “Atomic Bomb Disease Medicine”, “International Radiation Health Sciences”, and “Radiation Basic Life Sciences”. Each paper was discussed actively and “Global Strategic Center for Radiation Health Risk Control” has embarked on full-scale activity.
Two 1-day international seminars were held on February 2nd for fields of “Cancer Research”, “Radiation Basic Life Sciences”, and 4th for the fields of “Radiation Risk Management”, “Disasters and Mental Health”, “Radiation and Cancer”, “Chernobyl/Semipalatinsk Nuclear Test Site-related Issues” as satellite meetings of the symposium. A number of papers were presented by graduate students of the university as well as overseas and domestic participants of the symposium, and ideas about future activities in the fields were exchanged actively. Papers presented at the symposium and the satellite meetings will be compiled and published by Springer Japan Inc. in this October. The program of the symposium was as follows.

Program Venue: Matsumoto Ryojun Hall,
Nagasaki University School of Medicine

Main Meeting

Day1 (31 January)
10:30-11:10Opening ceremony
Chair: Shunichi Yamashita, GCOE Program Leader, Nagasaki University
10:30-10:40 Opening address
Hiroshi Saito, President, Nagasaki University
10:40-11:10 Addresses
 Yoshiharu Yonekura, President, National Institute of Radiological Sciences, Chiba, Japan
Toshiteru Okubo, Chairman, Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan
Kenzo Kiikuni, Chairman, Sasakawa Memorial Health Foundation, Tokyo, Japan
Kenji Kamiya, President, The Japan Radiation Research Society, Hiroshima, Japan
Masao Tomonaga, Dean, Nagasaki University Graduate School of Biomedical Sciences
11:10-11:40Overview of GCOE Program
Overview of GCOE program: global strategic center for radiation health risk control
 Shunichi Yamashita, GCOE Program Leader, Nagasaki University
11:40-13:30Group photo, Lunch, and Press conference
13:30-16:30 Overview Lectures
Chairs: Tom K. Hei, Columbia University, New York, NY, USA and Yuji Nagayama, Nagasaki University
Discussion points on radiation safety, and scope of the University of Tokyo Global COE program
 Takeshi Iimoto and Toshiso Kosako, The University of Tokyo, Tokyo, Japan
WHO role in strengthening global preparedness and response to radiation emergencies
 Zhanat Carr, WHO Headquarters, Geneva, Switzerland
Network system for radiation emergency medicine in Japan and the role of Hiroshima University
 Kenji Kamiya, Hiroshima University, Hiroshima, Japan
Non-(DNA)-targeted effects and low-dose radiation risk
 Barry D. Michael, Oxford University Gray Cancer Institute, Northwood, UK
Update from the Chernobyl Tissue Bank: effect of latency on different types of thyroid cancer post Chernobyl
 Geraldine A. Thomas, Hammersmith Hospital, London, UK
Current risk estimate of radiation-related cancer and our insight into the future
   Michiaki Kai, Oita University of Nursing and Health Sciences, Oita, Japan
Day 2 (1 February)
9:00-11:45 Atomic Bomb Disease Medicine
Chairs: Ichiro Sekine and Kunihiro Tsukasaki, Nagasaki University
9:00-9:15 Introduction of atomic bomb disease medical research in Global COE program
 Kunihiro Tsukasaki, Project Leader, Nagasaki University
9:15-11:45 Outstanding Topics
The children of A-bomb survivors: mortality and cancer incidence
 Akihiko Suyama, Radiation Effects Research Foundation, Nagasaki, Japan
Ischemic heart disease among atomic bomb survivors: possible mechanism(s) linking ischemic heart disease and radiation exposure
 Masazumi Akahoshi, Radiation Effects Research Foundation, Nagasaki, Japan
Leukemia, lymphoma, and multiple myeloma incidence in the LSS cohort: 1950-2001
 Wan-Ling Hsu, Radiation Effects Research Foundation, Hiroshima, Japan
Follow-up study on 78 heavily exposed atomic bomb survivors for 35 years in Hiroshima
 Nanao Kamada, Hiroshima Atomic Bomb Survivors Relief Foundation, Hiroshima, Japan
13:00-15:15International Radiation Health Sciences
Chairs: Hiroki Ozawa and Noboru Takamura, Nagasaki University
13:00-13:15 Introduction of research activities and projects within a framework of international radiation health sciences research
 Noboru Takamura, Project Leader, Nagasaki University
13:15-15:15 Outstanding Topics
Age and prognosis- do adjuvant therapies influence the real prognosis?
 Robert C. Leonard, Imperial College School of Medicine, London, UK
Mortality of the Chernobyl emergency workers: analysis of dose response (cohort studies, 1992-2006)
 Victor Ivanov, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk, Russia
Twenty years after Chernobyl: implications for radiation health risk control
 Yoshisada Shibata, GCOE Professor, Nagasaki University
Fallout exposure of the population and thyroid nodular diseases
 Zhaxybay Zhumadilov, Semipalatinsk State Medical Academy, Semipalatinsk, Kazakhstan
15:15-15:30Coffee break
15:30-17:30Radiation Basic Life Sciences
Chairs: Masami Watanabe, Kyoto University and Keiji Suzuki, Nagasaki University
Higher-order chromatin structure and non-targeted effects
 Keiji Suzuki, Nagasaki University
P53 dependency of delayed and untargeted recombination in mouse embryos fertilized by irradiated sperm
 Ohtsura Niwa, National Institute of Radiological Sciences, Chiba, Japan
The ying and the yang of low dose radiobiology
 Tom K. Hei, Columbia University, New York, NY, USA
In the pursuit of identifying biomarkers of radiation exposure in human lymphocytes: a multi-parameteric approach
 Prakash M. Hande, National University of Singapore, Singapore
17:30Closing remarks
Shunichi Yamashita, GCOE Program Leader, Nagasaki University

Satellite Meeting

Day 1 (2 February)
9:00-12:00Cancer Research
Chair: Yuji Nagayama, Nagasaki University
Molecular understandings on RET/PTC-mediated thyroid carcinogenesis
 Minho Shong, Chungnam National University School of Medicine, Daejeon, Korea
Chair: Koh-ichiro Yoshiura, Nagasaki University
Molecular prediction of therapeutic response and adverse effect of chemotherapy in breast cancer
 Yoshio Miki, Tokyo Medical and Dental University, Tokyo, Japan
Chair: Keiji Suzuki, Nagasaki University
Multiple roles of NBS1 for genotoxic and non-genotoxic stresses
 Kenshi Komatsu, Kyoto University, Kyoto, Japan
13:00-16:45Radiation Basic Life Sciences
Chairs: Alex J. van der Eb, Leiden University Medical Center, Leiden, Netherlands and Takeo Ohnishi, Nara Medical University, Nara, Japan
The DNA damage response in non-targeted cells
 Kevin M. Prise, Queen’s University Belfast, Belfast, UK
The role of telomere dysfunction in driving genomic instability
 Robert L. Ullrich, Colorado State University, Fort Collins, CO, USA
Insulin-like growth factor-secretory clusterin (IGF-1-sCLU) expression: a sensitive measure of DNA damage and general genomic instability
 David A. Boothman, University of Texas Southwestern Medical Center, Dallas, TX, USA
Target of radiation carcinogenesis is protein
 Masami Watanabe, Kyoto University, Kyoto, Japan
15:00-15:15 Coffee break
Extrapolation from high level ionizing radiation to low level exposures involves a shift from the genotoxicity paradigm to the epigenetic signaling paradigm
 James E. Trosko, Michigan State University, East Lansing, MI, USA
Combined effect of ionizing radiation and N-ethyl-N-nitrosourea on mutation induction and lymphoma development
 Yoshiya Shimada, National Institute of Radiological Sciences, Chiba, Japan
γ-ray induced mouse thymic lymphomas: multi-step carcinogenesis and pre-lymphoma cells
 Ryo Kominami, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
16:45Closing remarks
Yuji Nagayama, Project Leader, Nagasaki University
Day 2 (4 February)
Fumio Suzuki, Director, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
9:00-10:30Radiation Risk Management
Chairs: Akira Ohtsuru and Naoki Matsuda, Nagasaki University
Framework of radiation safety management in Japan: laws, administrative agencies, and supporting associations
 Naoki Matsuda, Nagasaki University
Background radiation dose to the population around Kudankulam nuclear power plant
 Subramaniyan Selvasekarapandian, Bharathiar University, Coimbatore, India
International cooperation in radiation emergency medical preparedness: medical network in Asia
 Makoto Akashi, National Institute of Radiological Sciences, Chiba, Japan
10:30-12:00Disaster and Mental Health
Chairs: Hiroki Ozawa and Yoshisada Shibata, Nagasaki University
Long term bio-psycho-social consequences of disaster
 Naotaka Shinfuku, Seinan Gakuin University, Fukuoka, Japan
Health status in children exposed to the Chernobyl accident in utero: observations in 1989-2003 and their implications for prioritizing prophylactic programs
 Nataliya Korol, Research Center for Radiation Medicine of AMSU, Kiev, Ukraine
Mental health issues after a radioactive disaster
 Yuriko Suzuki, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo, Japan
13:00-14:30Radiation and Cancer
Chairs: Masahiro Nakashima and Koh-ichiro Yoshiura, Nagasaki University
Downregulation of a candidate myeloid tumor suppressor gene isolated from 7q21 induces abnormal mitosis due to insufficient centrosome maturation, session type
 Hiroya Asou, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
Significance of oncogene amplifications in breast cancer in atomic bomb survivors: associations with radiation exposure and histological grade
 Shiro Miura, Nagasaki University
Paracrine interactions between normal, but not cancer epithelial and normal mesenchymal cells attenuate radiation-induced DNA damage
 Vladimir Saenko, Nagasaki University
14:30-14:45Coffee break
14:45-15:55Chernobyl-/Semipalatinsk Nuclear Test Site-related Issues
Chairs: Aikan Akanov and Noboru Takamura, Nagasaki University
Thyroid cancer in Ukraine after the Chernobyl accident: incidence, pathology, treatment, and molecular biology
 Mykola Tronko, Institute of Endocrinology and Metabolism of AMSU, Kiev, Ukraine
Current trends in incidence and mortality from thyroid carcinomas in Belarus
 Pavel I. Bespalchuk, Belarussian State Medical University, Minsk, Belarus
The status of health of the population of Semipalatinsk region and the scientifically-proved measures of its improvement
 Tolebay K. Rakhypbekov, Semipalatinsk State Medical Academy, Semipalatinsk, Kazakhstan
Atomic bomb disease and public health development
 Aikan Akanov and Serik Meirmanov, Nagasaki University

15:55Closing remarks
Noboru Takamura, Project Leader, Nagasaki University

  International Radiation Health Sciences Research
    Atomic Bomb Disease Medicine Research
    Radiation Basic Life Sciences Research
    Workshop / Special Meeting
    Academic Exchange
    Reports on Overseas' Conferences and Meetings
    Cooperation with WHO
Publicity Activities
  Truth of radiology (in Japanese)
  Radiation Q&A (in Japanese)
    Introduction of Global Strategic Center for Radiation Health Risk Control
(in Japanese) [PDF 9MB]
    Visiting Report of Chelnobyl
Yasuyuki Taira, Graduate Student
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