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The First International Symposium on
Establishment of a new discipline “Medical Care for
Hibakusha” |
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In commemoration of Nagasaki
University “Global Strategic Center for Radiation Health
Risk Control” being selected as one of the winners of
the “FY 2007 Global COE Program”, The First International
Symposium on the Establishment of a New Discipline “Medical
Care for Hibakusha” was held on January 31st and February
1st, 2008 at Matsumoto Ryojun Hall, Nagasaki University School
of Medicine. The number of participants amounted to about 150,
including guests, delegates from universities and institutes
which have joined or are to join the consortium and domestic
researchers inside and outside the university, and the symposium
was led to success.
The opening ceremony of the symposium was commenced with the
opening address by Dr. Hiroshi Saito, President of Nagasaki
University, followed by addresses of four guests, Dr. Yoshiharu
Yonekura (President, National Institute of Radiological Sciences),
Dr. Toshiteru Okubo (Chairman, Radiation Effects Research Foundation),
Dr. Kenzo Kiikuni (Chairman, Sasakawa Memorial Health Foundation),
and Dr. Kenji Kamiya (President, The Japan Radiation Research
Society) and ended with introduction to the COE program by
Prof. Shunichi Yamashita of Project Leader. The first day of
the symposium ended with the overview lectures given by Associate
Prof. Takeshi Iimoto (Global COE, The University of Tokyo),
Dr. Zhanat Carr (Scientist, WHO Headquarters), Prof. Kenji
Kamiya (21st Century COE, Hiroshima University), Prof. Barry
Michael (University of Oxford, Gray Cancer Institute), Prof.
Geraldine Thomas (Hammersmith Hospital), and Prof. Michiaki
Kai (Oita University of Nursing and Health Sciences). On the
second day of the symposium, a total of 14 papers were presented
at the three sessions of “Atomic Bomb Disease Medicine”, “International
Radiation Health Sciences”, and “Radiation Basic
Life Sciences”. Each paper was discussed actively and “Global
Strategic Center for Radiation Health Risk Control” has
embarked on full-scale activity.
Two 1-day international seminars were held on February 2nd
for fields of “Cancer Research”, “Radiation
Basic Life Sciences”, and 4th for the fields of “Radiation
Risk Management”, “Disasters and Mental Health”, “Radiation
and Cancer”, “Chernobyl/Semipalatinsk Nuclear Test
Site-related Issues” as satellite meetings of the symposium.
A number of papers were presented by graduate students of the
university as well as overseas and domestic participants of
the symposium, and ideas about future activities in the fields
were exchanged actively. Papers presented at the symposium
and the satellite meetings will be compiled and published by
Springer Japan Inc. in this October. The program of the symposium
was as follows. |
| Program | Venue: Matsumoto Ryojun Hall,
Nagasaki University School of Medicine |
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| 10:30-11:10 | Opening ceremony
Chair: Shunichi Yamashita, GCOE Program Leader, Nagasaki University
10:30-10:40 Opening address
Hiroshi Saito, President, Nagasaki University
10:40-11:10 Addresses |
| | Yoshiharu Yonekura, President, National Institute of
Radiological Sciences, Chiba, Japan
Toshiteru Okubo, Chairman, Radiation Effects Research Foundation, Hiroshima
and Nagasaki, Japan
Kenzo Kiikuni, Chairman, Sasakawa Memorial Health Foundation, Tokyo,
Japan
Kenji Kamiya, President, The Japan Radiation Research Society, Hiroshima,
Japan
Masao Tomonaga, Dean, Nagasaki University Graduate School of Biomedical
Sciences |
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| 11:10-11:40 | Overview of GCOE Program
Overview of GCOE program: global strategic center for
radiation health risk control |
| | Shunichi Yamashita, GCOE Program Leader, Nagasaki University |
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| 11:40-13:30 | Group photo, Lunch, and Press conference |
|
| 13:30-16:30 | Overview Lectures
Chairs: Tom K. Hei, Columbia University, New York, NY, USA and Yuji
Nagayama, Nagasaki University |
| | | Discussion points on radiation safety, and scope of the University
of Tokyo Global COE program | | | Takeshi Iimoto and Toshiso Kosako,
The University of Tokyo, Tokyo, Japan | | WHO role in strengthening global preparedness and response to radiation emergencies | | | Zhanat Carr, WHO Headquarters, Geneva, Switzerland | | Network system for radiation emergency medicine in Japan and the role of Hiroshima
University | | | Kenji Kamiya, Hiroshima University, Hiroshima, Japan | | Non-(DNA)-targeted effects and low-dose radiation risk | | | Barry D. Michael, Oxford University Gray Cancer Institute,
Northwood, UK | | Update from the Chernobyl Tissue Bank: effect of latency on different types
of thyroid cancer post Chernobyl | | | Geraldine A. Thomas, Hammersmith Hospital, London,
UK | | Current risk estimate of radiation-related cancer and our insight into the future | | | Michiaki Kai, Oita University of Nursing and Health
Sciences, Oita, Japan |
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| 18:00-20:00 | Reception |
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| 9:00-11:45 | Atomic Bomb Disease Medicine
Chairs: Ichiro Sekine and Kunihiro Tsukasaki,
Nagasaki University |
| 9:00-9:15 Introduction
of atomic bomb disease medical research in Global COE program |
| | Kunihiro Tsukasaki, Project Leader, Nagasaki University |
| 9:15-11:45 Outstanding Topics |
| | | The children of A-bomb survivors: mortality and cancer incidence | | | Akihiko Suyama, Radiation Effects Research
Foundation, Nagasaki, Japan | | Ischemic heart disease among atomic bomb survivors: possible mechanism(s) linking
ischemic heart disease and radiation exposure | | | Masazumi Akahoshi, Radiation Effects Research Foundation,
Nagasaki, Japan | | Leukemia, lymphoma, and multiple myeloma incidence in the LSS cohort: 1950-2001 | | | Wan-Ling Hsu, Radiation Effects Research Foundation,
Hiroshima, Japan | | Follow-up study on 78 heavily exposed atomic bomb survivors for 35 years in
Hiroshima | | | Nanao Kamada, Hiroshima Atomic Bomb Survivors Relief
Foundation, Hiroshima, Japan |
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| 11:45-13:00 | Lunch |
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| 13:00-15:15 | International Radiation Health
Sciences
Chairs: Hiroki Ozawa and Noboru Takamura, Nagasaki University |
| 13:00-13:15 Introduction of research
activities and projects within a framework of international radiation health
sciences research |
| | Noboru Takamura, Project Leader, Nagasaki University |
| 13:15-15:15 Outstanding Topics |
| | | Age and prognosis- do adjuvant therapies influence the real
prognosis? | | | Robert C. Leonard, Imperial College
School of Medicine, London, UK | | Mortality of the Chernobyl emergency workers: analysis of dose response (cohort
studies, 1992-2006) | | | Victor Ivanov, Medical Radiological Research Center
of Russian Academy of Medical Sciences, Obninsk, Russia | | Twenty years after Chernobyl: implications for radiation health risk control | | | Yoshisada Shibata, GCOE Professor, Nagasaki University | | Fallout exposure of the population and thyroid nodular diseases | | | Zhaxybay Zhumadilov, Semipalatinsk State Medical Academy,
Semipalatinsk, Kazakhstan |
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| 15:15-15:30 | Coffee break |
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| 15:30-17:30 | Radiation Basic Life Sciences
Chairs: Masami Watanabe, Kyoto University and Keiji Suzuki,
Nagasaki University |
| | | Higher-order chromatin structure and non-targeted effects | | | Keiji Suzuki, Nagasaki University | | P53 dependency of delayed and untargeted recombination in mouse embryos fertilized
by irradiated sperm | | | Ohtsura Niwa, National Institute of Radiological Sciences,
Chiba, Japan | | The ying and the yang of low dose radiobiology | | | Tom K. Hei, Columbia University, New York, NY, USA | | In the pursuit of identifying biomarkers of radiation exposure in human lymphocytes:
a multi-parameteric approach | | | Prakash M. Hande, National University of Singapore,
Singapore |
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| 17:30 | Closing remarks
Shunichi Yamashita, GCOE Program Leader, Nagasaki University |
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| 9:00-12:00 | Cancer Research
Chair: Yuji Nagayama, Nagasaki University |
| | | Molecular understandings on RET/PTC-mediated thyroid carcinogenesis | | | Minho Shong, Chungnam National University
School of Medicine, Daejeon, Korea |
|
| Chair: Koh-ichiro Yoshiura, Nagasaki University |
| | | Molecular prediction of therapeutic response and adverse effect
of chemotherapy in breast cancer | | | Yoshio Miki, Tokyo Medical and Dental
University, Tokyo, Japan |
|
| Chair: Keiji Suzuki, Nagasaki University |
| | | Multiple roles of NBS1 for genotoxic and non-genotoxic stresses | | | Kenshi Komatsu, Kyoto University, Kyoto,
Japan |
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| 12:00-13:00 | Lunch |
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| 13:00-16:45 | Radiation Basic Life Sciences
Chairs: Alex J. van der Eb, Leiden University Medical Center, Leiden,
Netherlands and Takeo Ohnishi, Nara Medical University, Nara, Japan |
| | | The DNA damage response in non-targeted cells | | | Kevin M. Prise, Queen’s University
Belfast, Belfast, UK | | The role of telomere dysfunction in driving genomic instability | | | Robert L. Ullrich, Colorado State University, Fort
Collins, CO, USA | | Insulin-like growth factor-secretory clusterin (IGF-1-sCLU) expression: a sensitive
measure of DNA damage and general genomic instability | | | David A. Boothman, University of Texas Southwestern
Medical Center, Dallas, TX, USA | | Target of radiation carcinogenesis is protein | | | Masami Watanabe, Kyoto University, Kyoto, Japan |
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| 15:00-15:15 | Coffee break |
| | | | Extrapolation from high level ionizing radiation to low level
exposures involves a shift from the genotoxicity paradigm to the epigenetic signaling
paradigm | | | James E. Trosko, Michigan State University,
East Lansing, MI, USA | | Combined effect of ionizing radiation and N-ethyl-N-nitrosourea
on mutation induction and lymphoma development | | | Yoshiya Shimada, National Institute of Radiological
Sciences, Chiba, Japan | | γ-ray induced mouse thymic lymphomas: multi-step carcinogenesis and pre-lymphoma
cells | | | Ryo Kominami, Niigata University Graduate School of
Medical and Dental Sciences, Niigata, Japan |
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| 16:45 | Closing remarks
Yuji Nagayama, Project Leader, Nagasaki University |
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| 8:50-9:00 | Greetings
Fumio Suzuki, Director, Research Institute for Radiation Biology and
Medicine, Hiroshima University, Hiroshima, Japan |
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| 9:00-10:30 | Radiation Risk Management
Chairs: Akira Ohtsuru and Naoki Matsuda, Nagasaki University |
| | | | Framework of radiation safety management in Japan: laws, administrative
agencies, and supporting associations | | | Naoki Matsuda, Nagasaki University | | Background radiation dose to the population around Kudankulam nuclear power
plant | | | Subramaniyan Selvasekarapandian, Bharathiar University,
Coimbatore, India | | International cooperation in radiation emergency medical preparedness: medical
network in Asia | | | Makoto Akashi, National Institute of Radiological
Sciences, Chiba, Japan |
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|
| 10:30-12:00 | Disaster and Mental Health
Chairs: Hiroki Ozawa and Yoshisada Shibata, Nagasaki University |
| | | | Long term bio-psycho-social consequences of disaster | | | Naotaka Shinfuku, Seinan Gakuin University, Fukuoka, Japan | | Health status in children exposed to the Chernobyl accident in utero: observations
in 1989-2003 and their implications for prioritizing prophylactic programs | | | Nataliya Korol, Research Center for Radiation Medicine
of AMSU, Kiev, Ukraine | | Mental health issues after a radioactive disaster | | | Yuriko Suzuki, National Center of Neurology and Psychiatry,
National Institute of Mental Health, Tokyo, Japan |
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| 12:00-13:00 | Lunch |
|
| 13:00-14:30 | Radiation and Cancer
Chairs: Masahiro Nakashima and Koh-ichiro Yoshiura, Nagasaki
University |
| | | Downregulation of a candidate myeloid tumor suppressor
gene isolated from 7q21 induces abnormal mitosis due to insufficient centrosome
maturation, session type | | | Hiroya Asou, Research Institute for
Radiation Biology and Medicine, Hiroshima University, Hiroshima,
Japan | | Significance of oncogene amplifications in breast cancer in atomic bomb survivors:
associations with radiation exposure and histological grade | | | Shiro Miura, Nagasaki University | | Paracrine interactions between normal, but not cancer epithelial and normal
mesenchymal cells attenuate radiation-induced DNA damage | | | Vladimir Saenko, Nagasaki University |
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| 14:30-14:45 | Coffee break |
|
| 14:45-15:55 | Chernobyl-/Semipalatinsk Nuclear
Test Site-related Issues
Chairs: Aikan Akanov and Noboru Takamura, Nagasaki University |
| | | Thyroid cancer in Ukraine after the Chernobyl accident: incidence,
pathology, treatment, and molecular biology | | | Mykola Tronko, Institute of Endocrinology
and Metabolism of AMSU, Kiev, Ukraine | | Current trends in incidence and mortality from thyroid carcinomas in Belarus | | | Pavel I. Bespalchuk, Belarussian State Medical University,
Minsk, Belarus | | The status of health of the population of Semipalatinsk region and the scientifically-proved
measures of its improvement | | | Tolebay K. Rakhypbekov, Semipalatinsk State Medical
Academy, Semipalatinsk, Kazakhstan | | Atomic bomb disease and public health development | | | Aikan Akanov and Serik Meirmanov, Nagasaki University |
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| 15:55 | Closing remarks
Noboru Takamura, Project Leader, Nagasaki University |
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