小動物PET/SPECT/CTによる前臨床分子イメージング

英文

• Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K. Transport Mechanisms of Hepatic Uptake and Bile Excretion in Clinical Hepatobiliary Scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. Nucl Med Biol 41 (4): 338-342, 2014
• Matsunari I, Miyazaki Y, Kobayashi M, Nishi K, Mizutani A, Kawai K, Hayashi A, Komatsu R, Yonezawa S, Kinuya S. Performance evaluation of the eXplore speCZT preclinical imaging system. Ann Nucl Med 28 (5): 484-497, 2014
• Mizutani A, Matsunari I, Kobayashi M, Nishi K, Fujita W, Miyazaki Y, Nekolla SG, Keiichi Kawai: Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat. EJNMMI Phys. Dec; 2(1): 7, 2015
• Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K: In vivo radioactive metabolite analysis for individualized medicine: A basic study of a new method of CYP activity assay using 123I-IMP. Nucl Med Biol. 42(2): 171-176; 2015
• Mizuta S, Otaki H, Kitamura K, Nishi K, Watanabe K, Makau JN, Hashimoto R, Usui T, Chiba K: 3,3-Dibromo-2-trifluoromethyl Acrylic Acid Ethyl Ester: A Versatile Platform for the Stereoselective Preparation of Functionalized- α-Trifluoromethyl α,β-Unsaturated Lactones and Trifluoromethyl Pyrazolinones. Org. Chem. Front. 2016. 3, 1661-1667; 2016
• Mizuta S, Kitamura K, Nishi K, Hashimoto R, Usui T, Chiba K: Activity of N,N’-dialkyl-2-trifluoromethyl-thioimidazolium salts as phase- transfer catalyst for the alkylation of active methylene compounds. RSC Adv. 6:43159-43162; 2016
• Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, Sugama J, Shiba K, Kawai K, Kinuya S: Simultaneous acquisition of 99mTc and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detector. Ann Nucl Med. 30(4):263-71; 2016
• Shimada S, Aoki K, Nabeshima T, Fuxun Y, Kurosaki Y, Shiogama K, Onouchi T, Sakaguchi M, Fuchigami T, Ono H, Nishi K, Posadas-Herrera G, Uchida L, Takamatsu Y, Yasuda J, Tsutsumi Y, Fujita H, Morita K, Hayasaka D: Tofla virus: A newly identified Nairovirus of the Crimean-Congo hemorrhagic fever group isolated from ticks in Japan. Sci Rep 6:20213; 2016
• Hayasaka D, Nishi K, Fuchigami T, Shiogama K, Onouchi T, Shimada S, Tsutsumi Y, Morita K: 18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model. Oncotarget. 7 (1):140-147; 2016
• Fuchigami T, Ono H, Oyadomari K, Iwatake M, Hayasaka D, Akbari M, Yui K, Nishi K, Kudo T, Yoshida S, Haratake M, Nakayama M: Development of a 68Ge/68Ga generator system using polysaccharide polymers and its application in PET imaging of tropical infectious diseases. ACS Omega 2(4): 1400-1407, 2017
• Mizuta S, Otaki H, Kitagawa A, Kitamura K, Morii Y, Ishihara J, Nishi K, Hashimoto R, Usui T, Chiba K: Ionic Liquid-Mediated Hydrofluorination of o-Azaxylylenes Derived from 3-Bromooxindoles. Org Lett. 19(10): 2572-2575, 2017
• Kobayashi M, Mizutani A, Nishi K, Nakajima S, Shikano N, Nishii R, Fukuchi K, Kawai K: Difference in accumulation and the transport mechanism of L- and D-methionine in high- and low-grade human glioma cells. Nucl Med Biol, 14(44): 78-82, 2017
• Luo L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li TS, Cheng K: Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice. Circ Res. 120(11): 1768-1775, 2017
• Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS: Ionizing radiation impairs endogenous regeneration of infarcted heart: an in vivo 18F-FDG PET/CT and 99mTc-tetrofosmin SPECT/CT study in mice. Radiation Res. 187(1): 89-97, 2017.
• Wen JZ, Kobayashi M, Yamada K, Nishi K, Takahashi K, Mizutani A, Nishii R, Flores LG 2nd, Shikano N, Kunishima M, Kawai K. Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma. Nucl Med Biol. 59:16-21, 2018.
• Mizutani A, Kobayashi M, Fujita K, Takahashi K, Hokama T, Takasu H, Nishi K, Nishii R, Shikano N, Fukuchi K, Kawai K. 123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug-metabolizing enzyme activity. Nucl Med Commun. 39(9): 825-833, 2018.
• Kobayashi M, Tsujiuchi T, Okui Y, Mizutani A, Nishi K, Nakanishi T, Nishii R, Fukuchi K, Tamai I, Kawai K. Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer. Pharm Res. 36(1): 18, 2018.
• Kobayashi M, Kato T, Washiyama K, Ihara M, Mizutani A, Nishi K, Flores LG 2nd, Nishii R, Kawai K. The pharmacological properties of 3-arm or 4-arm DOTA constructs for conjugation to α-melanocyte-stimulating hormone analogues for melanoma imaging. PloS one 14(3) : e0213397, 2019
• Mizuta S, Makau JN, Kitagawa A, Kitamura K, Otaki H, Nishi K, Watanabe K. Synthesis of Trifluoromethyl-α,β-unsaturated Lactones and Pyrazolinones and Discovery of Influenza Virus Polymerase Inhibitors. ChemMedChem 13 (22) : 2390 - 2399, 2019
• Kobayashi M, Nishi K, Mizutani A, Hokama T, Matsue M, Tsujikawa T, Nakanishi T, Nishii R, Tamai I, Kawai K Imaging of hepatic drug transporters with 131I 6-β-iodomethyl-19-norcholesterol. Scientific reports 9 (1) : 13413, 2019
• Yoshida M, Tashiro M, Nishi K, Mishima M, Kawano K, Takazono T, Saijo T, Yamamoto K, Imamura Y, Miyazaki T, Kudo T, Yanagihara K, Mukae H and Izumikawa K: Detection of invasive pulmonary aspergillosis in mice using lung perfusion single-photon emission computed tomography with [99mTc]MAA. Med Mycol. 58(7): 965-972, 2020
• Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, Nishii R, Tamai I, Kawai K: Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells. Nucl Med Biol 84-85: 33-37, 2020
• Fuchigami T, Kawasaki M, Watanabe H, Nakagaki T, Nishi K, Sano K, Atarashi R, Nakaie M, Yoshida S, Ono M, Nishida N, Nakayama M: Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain. Nucl Med Biol 90-91: 41-48, 2020
• Kobayashi M, Mizutani A, Nishi K, Muranaka Y, Nishii R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K.: [131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma. Nucl Med Biol 90-91: 49-54, 2020
• Nishi K, Kudo T. : Chapter1-7 PET/CT for Inflammatory Diseases-Basic Science, Typical Cases, and Review : 34-37, 2020 .
• Nishi K, Kobayashi M, Kikuchi M, Mizutani A, Muranaka Y, Tamai I, Kawai K, Kudo T.: Inhibition of the Hepatic Uptake of (99m)Tc-Tetrofosmin Using an Organic Cation Transporter Blocker. Pharmaceutics 13(7): 1073,2021.
• Kinoshita T, Watanabe K, Sakurai Y, Nishi K, Yoshikawa R, Yasuda J: Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters. Scientific reports 11(1): 21259,2021.
• Kobayashi M, Mizutani A, OkamotoT, Muranaka Y, Nishi K, Nishii R, Shikano N, Nakanishi T, Tamai I, Eugenie SK, Kawai K: Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid. Nuclear Medicine and Biology 94-95: 92-97,2021.

邦文

• 西 弘大、松田尚樹、三浦美和、林田りか、山内基弘、平川美弥子、高尾秀明、工藤 崇：小動物分子イメージングの放射線施設への導入効果．日本放射線安全管理学会誌. 15 (1): 74-79; 2016
• 西 弘大．教育講座－放射線後術学を用いた先端生命科学研究－ 第10回「前臨床核医学の基礎と病態への応用」日本放射線技術学会雑誌 74巻10号 p1207-1211.

学会発表

• 西 弘大, 松田尚樹, 三浦美和, 林田りか, 山内基弘, 高尾秀明, 工藤 崇：小動物分子イメージングの放射線施設への導入効果. 日本放射線安全管理学会 第14回学術大会講演予稿集 p68 2015
• 高橋浩太郎, 水谷明日香, 佐野達哉, 外間つづみ, 西 弘大, 小林正和, 川井恵一：123I-IMP代謝物分析による臨床薬剤負荷時のCYP活性定量. 核医学S290, 2015
• 西 弘大, 三嶋麻揮, 田代将人, 吉田將孝, 池田英史, 泉川公一, 松田尚樹, 工藤 崇：浸潤性肺アスペルギルス症に対する肺血流SPECTの有用性の検討. 核医学52(3), S303, 2015
• 小林正和、水谷明日香、松成一朗、西 弘大、宮崎吉春、柴 和弘、川井恵一：CZT半導体検出器を搭載した小動物SPECTイメージングにおける投与放射能、コリメータと平滑化フィルター処理の影響. JSMI Report 8(2): 147; 2015
• 西 弘大、田代将人、吉田將孝、池田英史、三嶋麻揮、泉川公一、松田尚樹、工藤 崇：肺血流SPECTによるアスペルギルス感染マウスの経過観察.　JSMI Report 8(2): 169; 2015
• 三嶋麻揮、西 弘大、田代将人、辻野耕平、河野 圭、吉田將孝、松田尚樹、工藤 崇、泉川公一：Dynamic Imaging によるIPAモデルマウスにおける肺血流動態解析. 核医学. 53 (Supplement): S310, 2016
• 稲川耕平、丹羽隆博、西 弘大、小林正和、川井恵一：脳腫瘍細胞におけるD-methionineの集積生と集積機序の検討. 核医学. 53 (Supplement): S265, 2016
• 羅　蘭、西 弘大、Chen Y、浦田芳重、工藤 崇、李　桃生：放射線被ばくによる心血管疾患リスクに関する実験的評価. 第57回原子爆弾後障害研究会講演抄録p30
• 小林正和、水谷明日香、辻内孝文、西 弘大、福地一樹、川井恵一：99mTc放射性医薬品における腫瘍細胞外排泄機序の違い. JSMI Report. 9 (2): p203, 2016
• 有薗ケイラ、西　弘大、佛坂斉祉、森田幸子、橋本　恵、近藤崇伸、井野愛理、有田光太郎、黒濱武士、吉田教明：小動物用SPECTを用いた矯正力による歯槽骨の骨代謝変化の経過観察. 核医学57(Supplement), S208, 2017
• 西　弘大、小林正和、目代佑太朗、辻野耕平、川井恵一、工藤　崇：99mTc-tetrofosminの肝集積機序と輸送阻害効果. 核医学57(Supplement), S183, 2017
• 西　弘大、松田尚樹、工藤　崇：小動物分子イメージングの新領域への展開と応用.日本放射線安全管理学会第16回学術大会要旨集, p119, 2017
• 目代佑太朗、西　弘大、小林正和、辻野耕平、川井恵一、工藤　崇：99mTc-tetrofosminの肝集積メカニズムと肝集積阻害効果の検証. JSMI Report. 10(2), p154, 2017
• 西 弘大，松田尚樹，工藤 崇．前臨床分子イメージングエリアの室内放射線環境モニタリングの試み．日本放射線安全管理学会 第17回学術大会予稿集p34，2018年．