NAGASAKI UNIVERSITY GLOBAL COE PROGRAM - Global Strategic Center for Radiation Health Risk Control
Nagasaki University
Home>Activities>Reports on Overseas' Conferences and Meetings>Bulletin report on 78th annual meeting of American Thyroid Association
Reports on Overseas' Conferences and Meetings
Bulletin report on
78th annual meeting of American Thyroid Association

Yuji Nagayama, Department of Medical Gene Technology

78th annual meeting of American Thyroid Association was held at the Sheraton New York Hotel & Towers in New York City, USA on October 4 to 7, 2007. This hotel was located in the heart of the city but pretty old. Therefore, the air-conditioner did not work properly and I saw wide mice running in the room in the middle of night despite very expensive accommodation fee. Drs. S. Yamashita and N. Mitsutake in this Institute and also Dr. S. Maeda (a thyroid surgeon) in Nagasaki Medical Center, Omura participated in the meeting.
Although this meeting is relatively small in size with thyroidologists from north America, enthusiastic presentations and discussions were performed from early morning symposium to evening every day. In this meeting, numbers of papers on thyroid cancer is increasing, while those of thyroid autoimmunity decreasing recent years. Regarding thyroid cancer research, we found many interesting presentations such as analysis of gene expression profiling of mutant Braf transgenic mice, translation studies on molecular targeted therapy, analysis of intracellular signaling in cancer cells, and etc. However, the symposium on thyroid stem cells was a bit disappointing; most of data shown were expression analysis of stem cell-markers identified in other tissues/cells by RT-PCR. In thyroid autoimmunity, interesting papers include a novel therapeutic approach with an immuno-modulatory molecule TRAIL (TNF-related apoptosis-inducing ligand), and isolation of human monoclonal anti-TSH receptor antibody with blocking activity.
The following is the tile and abstract of our poster presentation.

 Nagayama Y, Nakahara M, Tone S, Abiru N.
Expression of Immuno-Regulatory Molecules on the Thyrocytes Protects NOD-H2h4 Mice from Developing Autoimmune Thyroiditis.

As one of the therapeutic approaches against autoimmune thyroid disease, we sought a potential to protect the target tissue (thyroid) from autoimmune reaction irrespective of its persistent activity. To this end, the immuno-regulatory molecules (TNF-related apoptosis-inducing ligand, TRAIL and indoleamine 2, 3-deoxygenase, IDO) were expressed on thyrocytes of NOD-H2h4 mice which spontaneously develop thyroiditis using recombinant adenovirus vectors. We found that these procedures significantly suppressed the degree of thyroiditis without altering the titers of anti-thyroglobulin antibodies or cytokine expression levels in spleen. These data indicate that this kind of immunological intervention, although it does not suppress autoimmune reaction itself, may have a potential for treating organ-specific autoimmune diseases.
  International Radiation Health Sciences Research
    Atomic Bomb Disease Medicine Research
    Radiation Basic Life Sciences Research
    Workshop / Special Meeting
    Academic Exchange
    Reports on Overseas' Conferences and Meetings
    Cooperation with WHO
Publicity Activities
  Truth of radiology (in Japanese)
  Radiation Q&A (in Japanese)
    Introduction of Global Strategic Center for Radiation Health Risk Control
(in Japanese) [PDF 9MB]
    Visiting Report of Chelnobyl
Yasuyuki Taira, Graduate Student
Related Links