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| Reports on Overseas' Conferences and
Meetings |
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| Report on Ataxia
Telangiectasia Workshop 2008 |
| Yasuyoshi Oka, Department
of Molecular Medicine and Hematology |
An Ataxia-Telangiectasia
Workshop 2008 was held in Shiga, Japan between
April 22 and 26, 2008. The basic to clinical
research on ATM protein is discussed in Ataxia-Telangiectasia
Workshop 2008.
ATM protein has critical roles in cell-cycle
regulation and DNA double-strand breaks repair
following induction of DNA double-strand breaks.
To investigate how DNA damage is recognized
by ATM, several types of DNA terminuses which
may be created after ionizing radiation are
generated and mixed with ATM in vitro. I doubted
whether this strategy contributed to shed
light on ATM function in a cell. Actually,
DNA is wrapped with histone proteins and forms
the higher-order chromatin conformation. I
realized that it was important to notice that
chromatin conformation after induction of
DNA double-strand breaks. I have to establish
new strategies and methods to unveil the real
ATM function. |
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