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The 68th Seminar

Development of hematopoietic stem cells

Dr. Shin-ichi Nishikawa
Deputy Director; Group Director of Laboratory for Stem Cell Biology,
Center for Developmental Biology, RIKEN


While where the hematopoietic progenitors emerge during embryogenesis has long been the matter of debate, not much is known under which molecular mechanisms HSC diverge from other lineages and what are the intermediate stages where a round of decision making to HSC takes place is totally unclear. This is the major question to which our group has been addressing. We are now feeling happy to be able to say that this question has been understood to a great extent by our studies over 10 years that specified three distinct intermediate stages and molecular networks driving this process. In this seminar, I will present how we explain this process. In addition, I would like to present some data of our analysis of genome-wide methylome of leukemic cell.
 
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