| Opening remarks |
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| 15:00- | | |
| | | Shunichi Yamashita, Global COE Leader |
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| General Lectures I |
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| 15:05- | Chair: | Yuji Nagayama, Department of Medical Gene Technology |
|
| | 1. Analysis of stress response factors in relation to regulation of radiosensitivity; |
| |
| (1) | Role of redox regulation by glutathione and glutaredoxin in radiosensitivity. |
| (2) | Role of calreticulin in radiosensitivity through regulaion of signal cascades. |
| (3) | Dehydroisoandrosterone (DHEA) increases cellular senescence in response to ionizing radiation. |
| (4) | Significance of mitochondrial glutathione S-transferase pi; The role of intracellular antioxidant system on the radiation sensitivity. |
|
| | | Kan Kageyama, Yoshishige Urata, and Shinji Goto, Department of Biochemistry and Molecular Biology in Disease |
| | 2. Alterations in higher-order chromatin structure and radiation-induced genomic instability. |
| | | Keiji Suzuki, Department of Molecular Medicine |
| | 3. Identification of molecular signature of radiation |
| | | Motohiro Yamauchi, Department of Molecular Medicine |
| | 4. Analysis of radiation risk perception by students and faculties, and evidence-based real-time estimation of internal exposure doses and its application for preliminary risk assessment. |
| | | Naoki Matsuda, Center for Frontier Life Sciences |
| |
| General Lectures II |
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| Chair: | Keiji Suzuki, Department of Molecular Medicine |
|
| | 5. Update of the molecular epidemiology study in radiation-induced thyroid cancer. |
| | | Vladimir Saenko, Department of International Health and Radiation Research |
| | 6. Basic research on thyroid carcinogenesis. |
| | | Norisato Mitsutake, Department of Molecular Medicine |
| | 7. Cancer-stroma cell interactions and radiation. |
| | | Ohki Saitoh, Department of Medical Gene Technology |
| | 8. Are Ret / PTC and mutant Braf authentic oncogenes for thyroid cancer? |
| | | Yuji Nagayama, Department of Medical Gene Technology |
| |
| General Lectures III |
|
| Chair: | Naoki Matsuda, Center for Frontier Life Sciences |
|
| | 9. Development of evaluation methods for irradiation effects on the human genomic structure and sequence: A preliminary report of detection of genomic rearrangements in irradiated normal human fibroblasts using DNA microarrays |
| | | Hiroyuki Mishima, Department of Human Genetics |
| | 10. Molecular pathologic characteristics of tumors from A-bomb survivors: analysis with archival paraffin-embedded tissues. |
| | | Masahiro Nakashima, Tissue and histopathology Section |
| | 11. The expression of DNA repair proteins in the X-irradiated intestinal tumor of Apc(min/+) mouse. |
| | | Toshiyuki Nakayama, Department of Tumor and Diagnostic Pathology |
| | 12. The effect of bFGF on acute radiation injury in small intestine of rats. |
| | | Mutsumi Matsuyama, Department of Tumor and Diagnostic Pathology |
| | 13. Radiosensitivity has relation to p53 mutation and DNA-PK activity. |
| | | Kumio Okaichi and Makoto Ihara, Department of Radiation Biophysics |
| |
| Special lectures |
|
| 19:00- | Chair: | Shunichi Yamashita, Global COE Leader |
|
| | 1. Mechanism of S-Nitrosylation. |
| | | Kan Kageyama, Department of Biochemistry and Molecular Biology in Disease |
| | 2. The roles of low-fidelity DNA polymerases in DNA repair mechanisms.DNA polymerase delta and kappa concertedly play roles in nucleotide excision repair. |
| | | Tomoo Ogi, Department of Molecular Medicine |
| |
| Closing remarks |
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| 20:00- | |
| | | Shunichi Yamashita, Global COE Leader |
