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The 6th Seminar

The 2nd reports on recent research


Program
Date: 3 April 2008 15:00-20:00Venue: Pompe van Meerdervoort Hall
Nagasaki University School of Medical Sciences

Opening remarks
15:00-  
  Shunichi Yamashita, Global COE Leader
 
General Lectures I
15:05-Chair: Yuji Nagayama, Department of Medical Gene Technology
 1. Analysis of stress response factors in relation to regulation of radiosensitivity;
 
(1) Role of redox regulation by glutathione and glutaredoxin in radiosensitivity.
(2) Role of calreticulin in radiosensitivity through regulaion of signal cascades.
(3)Dehydroisoandrosterone (DHEA) increases cellular senescence in response to ionizing radiation.
(4)Significance of mitochondrial glutathione S-transferase pi; The role of intracellular antioxidant system on the radiation sensitivity.
  Kan Kageyama, Yoshishige Urata, and Shinji Goto, Department of Biochemistry and Molecular Biology in Disease
 2. Alterations in higher-order chromatin structure and radiation-induced genomic instability.
  Keiji Suzuki, Department of Molecular Medicine
 3. Identification of molecular signature of radiation
  Motohiro Yamauchi, Department of Molecular Medicine
 4. Analysis of radiation risk perception by students and faculties, and evidence-based real-time estimation of internal exposure doses and its application for preliminary risk assessment.
  Naoki Matsuda, Center for Frontier Life Sciences
 
General Lectures II
Chair: Keiji Suzuki, Department of Molecular Medicine
 5. Update of the molecular epidemiology study in radiation-induced thyroid cancer.
  Vladimir Saenko, Department of International Health and Radiation Research
 6. Basic research on thyroid carcinogenesis.
  Norisato Mitsutake, Department of Molecular Medicine
 7. Cancer-stroma cell interactions and radiation.
  Ohki Saitoh, Department of Medical Gene Technology
 8. Are Ret / PTC and mutant Braf authentic oncogenes for thyroid cancer?
  Yuji Nagayama, Department of Medical Gene Technology
 
General Lectures III
Chair: Naoki Matsuda, Center for Frontier Life Sciences
 9. Development of evaluation methods for irradiation effects on the human genomic structure and sequence: A preliminary report of detection of genomic rearrangements in irradiated normal human fibroblasts using DNA microarrays
  Hiroyuki Mishima, Department of Human Genetics
 10. Molecular pathologic characteristics of tumors from A-bomb survivors: analysis with archival paraffin-embedded tissues.
  Masahiro Nakashima, Tissue and histopathology Section
 11. The expression of DNA repair proteins in the X-irradiated intestinal tumor of Apc(min/+) mouse.
  Toshiyuki Nakayama, Department of Tumor and Diagnostic Pathology
 12. The effect of bFGF on acute radiation injury in small intestine of rats.
  Mutsumi Matsuyama, Department of Tumor and Diagnostic Pathology
 13. Radiosensitivity has relation to p53 mutation and DNA-PK activity.
  Kumio Okaichi and Makoto Ihara, Department of Radiation Biophysics
 
Special lectures
19:00-Chair: Shunichi Yamashita, Global COE Leader
 1. Mechanism of S-Nitrosylation.
  Kan Kageyama, Department of Biochemistry and Molecular Biology in Disease
 2. The roles of low-fidelity DNA polymerases in DNA repair mechanisms.DNA polymerase delta and kappa concertedly play roles in nucleotide excision repair.
  Tomoo Ogi, Department of Molecular Medicine
 
Closing remarks
20:00- 
  Shunichi Yamashita, Global COE Leader
 
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