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| The role of phosphorylation in non-homologous end joining |
Prof. Susan P. Lees-Miller
Department of Biochemistry & Molecular Biology and Southern Alberta Cancer Research Institute,
The University of Calgary, Canada |
| In mammalian cells, the major pathway for the repair of IR-induced DSBs is NHEJ, which is template independent and functions throughout the cell cycle. Proteins shown to be required for NHEJ include the Ku70/80 heterodimer, the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), XRCC4, DNA ligase IV, Artemis and XLF. Additional proteins such as polynucleotide kinase (PNK) and DNA polymerases of the pol X family may also play a role in NHEJ. Here, I will discuss our recent studies on the role of the DNA-dependent protein kinase in NHEJ. |
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